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ABSTRACT Five primary prostanoids are synthesized by the cyclooxygenase enzymes, COX-1 and COX-2: the prostaglandins PGE2, PGF2α, PGI2, PGD2 and thromboxane A2. High levels of these

signaling molecules have been implicated—in both animal models and human studies—in decreased functional bladder capacity and micturition volume and increased voiding contraction amplitude.

Thus, inhibition of prostanoid production or the use of prostanoid receptor antagonists, might be a rational way to treat patients with detrusor muscle overactivity. Similarly, prostanoid

receptor agonists, or agents that stimulate their production, might have a function in treating bladder underactivity. Although some promising results have been reported, the adverse effects

of nonselective cyclooxygenase inhibitors are a major concern that restricts their use in the treatment of functional bladder disorders. Further preclinical and clinical studies are needed

before cyclooxygenase inhibitors, prostanoid receptor agonists and antagonists become worthwhile therapeutic tools in this setting. Access through your institution Buy or subscribe This is a

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DETRUSOR PDGFRΑ+ CELLS IN MOUSE MODEL OF CYCLOPHOSPHAMIDE-INDUCED DETRUSOR OVERACTIVITY Article Open access 24 March 2022 AGEING INFLUENCES DETRUSOR CONTRACTIONS TO PROSTAGLANDIN,

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overactive bladder in healthy young and elderly subjects [abstract]. _Eur. Urol._ 9 (Suppl.), 250 (2010). Article  Google Scholar  Download references ACKNOWLEDGEMENTS This study was

supported, in part, by an unconditional personal research grant (Mozaïek) to M. S. Rahnama'i by The Netherlands Organisation for Scientific Research (NWO). We are grateful to Dr Jan de

Vente for his help with the preparation of this manuscript. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Urology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ,

Maastricht, The Netherlands Mohammad S. Rahnama'i, Philip E. V. van Kerrebroeck, Stefan G. de Wachter & Gommert A. van Koeveringe Authors * Mohammad S. Rahnama'i View author

publications You can also search for this author inPubMed Google Scholar * Philip E. V. van Kerrebroeck View author publications You can also search for this author inPubMed Google Scholar *

Stefan G. de Wachter View author publications You can also search for this author inPubMed Google Scholar * Gommert A. van Koeveringe View author publications You can also search for this

author inPubMed Google Scholar CONTRIBUTIONS M. S. Rahnama'i researched the data for the article and wrote the manuscript. G. A. van Koeveringe contributed to the discussions of its

content. All authors reviewed and edited the manuscript before submission. CORRESPONDING AUTHOR Correspondence to Mohammad S. Rahnama'i. ETHICS DECLARATIONS COMPETING INTERESTS G. A.

van Koeveringe declares that he has been on the advisory boards for Allergan and Astellas Pharma. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE

Rahnama'i, M., van Kerrebroeck, P., de Wachter, S. _et al._ The role of prostanoids in urinary bladder physiology. _Nat Rev Urol_ 9, 283–290 (2012).

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