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Access through your institution Buy or subscribe The development of a new mouse model by Rodriguez _ et al_. has provided insights into the synergistic action of prostate-specific

G-protein-coupled receptor (PSGR) overexpression and phosphatase and tensin homologue (PTEN) loss in the progression of prostate cancer. _PTEN_ is the most frequently deleted

tumour-supressor gene in prostate cancer and its loss predicts poor prognosis and progression to a castration-resistant phenotype. Rodriguez and colleagues observed that _PTEN_ was deleted

or mutated in 21% of prostate cancers according to TCGA analysis. Conversely, PSGR is overexpressed in prostate tumours and expression levels correlate with cancer progression; when the team

investigated genomic data sets they found that four of 10 displayed _PSGR_ upregulation. This is a preview of subscription content, access via your institution RELEVANT ARTICLES Open Access

articles citing this article. * METHYLATION PATTERN ANALYSIS IN PROSTATE CANCER TISSUE: IDENTIFICATION OF BIOMARKERS USING AN MS-MLPA APPROACH * Giorgia Gurioli * , Samanta Salvi *  … 

Valentina Casadio _Journal of Translational Medicine_ Open Access 30 August 2016 ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online

access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which

are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Rodriguez, M. _ et al_.

Prostate-specific G-protein-coupled receptor collaborates with loss of PTEN to promote prostate cancer progression. _Oncogene_ 10.1038/onc.2015.170 Download references Authors * Louise Stone

View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Stone, L. PTEN loss

and PSGR overexpression promote cancer progression. _Nat Rev Urol_ 12, 364 (2015). https://doi.org/10.1038/nrurol.2015.147 Download citation * Published: 16 June 2015 * Issue Date: July

2015 * DOI: https://doi.org/10.1038/nrurol.2015.147 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link

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