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Peptide loading of major histocompatibility complex (MHC) class II molecules in the endosomes and lysosomes of antigen-presenting cells is catalyzed by human leukocyte antigen-DM (HLA-DM)

and modulated by HLA-DO. In a structural study in this issue, Guce _et al_. show that HLA-DO is an MHC class II mimic and functions as a competitive and essentially irreversible inhibitor of

HLA-DM activity, thereby inhibiting MHC class II antigen presentation. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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AFFILIATIONS * Lisa K. Denzin is at the Child Health Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New

Jersey, USA., Lisa K. Denzin * Peter Cresswell is at the Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.,

Peter Cresswell Authors * Lisa K. Denzin View author publications You can also search for this author inPubMed Google Scholar * Peter Cresswell View author publications You can also search

for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Lisa K. Denzin or Peter Cresswell. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing

financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Denzin, L., Cresswell, P. Sibling rivalry: competition between MHC class II family

members inhibits immunity. _Nat Struct Mol Biol_ 20, 7–10 (2013). https://doi.org/10.1038/nsmb.2484 Download citation * Published: 04 January 2013 * Issue Date: January 2013 * DOI:

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