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ABSTRACT Girls with idiopathic scoliosis are taller and thinner than comparable nonscoliotic controls. The difference may be related to the growth hormone (GH) and for this reason GH was

determined in plasma by double antibody radioimmurioassay under the following conditions: 1. insulin hypoglycemia, 2. glucose tolerance test, 3. exercise. After overnight fasting and after

at least 1 hour of rest the basal GH level was 9.8±11.1 (±SD)ng/ml in the scoliotic girls (n=48) and 2.2±1.1 ng/ml in the controls (n=15). The difference is significant. In the insulin

hypoglycemia test the peak GH value was 33.2±19.1 ng/ml in the scoliotic girls (n=27) and 20.8±8.3 ng/ml in the controls (n=8). This difference is, however, not significant. In the exercise

test the maximal value was observed at different times after the start of the test: at 20 minutes in the scoliotic girls (n=l4, GH 17.3 ± 11.8 ng/ml) and at 40 minutes in the controls (n=9,

GH 16.0±6.6 ng/ml). In the glucose tolerance test the GH levels was suppressed in both groups but the mean GH levels tended to be higher during the first 120 minutes of the test in the

scoliotic girls. The observed differences in the growth hormone response during the various tests, including statistically significantly higher basal values, could indicate an increased GH

secretion in idiopathic scoliosis. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Depart. of Paediatrics & Orthop. Surgery, Univ. of Lund. Malmo General Hospital., Sweden S

Willner, K O Nilsson & C G Bergstrand Authors * S Willner View author publications You can also search for this author inPubMed Google Scholar * K O Nilsson View author publications You

can also search for this author inPubMed Google Scholar * C G Bergstrand View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints

and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Willner, S., Nilsson, K. & Bergstrand, C. PLASMA GROWTH HORMONE LEVELS IN GIRLS WITH ADOLESCENT IDIOPATHIC SCOLIOSIS. _Pediatr Res_

9, 690 (1975). https://doi.org/10.1203/00006450-197508000-00141 Download citation * Issue Date: 01 August 1975 * DOI: https://doi.org/10.1203/00006450-197508000-00141 SHARE THIS ARTICLE

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