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ABSTRACT Summary: In adults of several species including man, a small transient decrease in serum calcium concentration follows glucagon administration in doses of 1 to 10 mg/kg. The effects

of maturation and insulin on this phenomenon were assessed by comparing the response of newborn and adult rats to equivalent doses of glucagon with and without prior insulin administration.

After injection of 1 μg/g of glucagon, the decrease in serum calcium concentration at 60 min was significant in the newborn rats (-1.75 mg/dl; P < 0.001) and not significant in the

intact adults (-0.07 mg/dl; P > 0.1). In pancreatomized adults, the decrease in serum calcium after the same dose of glucagon became significant (-1.23 mg/dl; _P_ ≤ 0.01). This

hypocalcemic effect was prevented in the pancreatectomized adult rat if insulin in a dose of 0.01 μg was given 15 min before glucagon. In the newborn rats, the same dose of insulin decreased

the hypocalcemic effect, but the change was still significant (-0.74 mg/dl; _P_ ≤ 0.01). Glucagon decreased serum calcium at one hr in newborn rats but not in adults. After pancreatectomy,

the adult response to glucagon was significant and similar to that of the newborn. Insulin cancelled this effect of glucagon in the pancreatectomized adults and reduced it in the newborns.

Speculation: Hypocalcemia in the neonatal period is a common and probably multifactorial disorder. Glucagon is known to be a hypocalcemic agent; this effect is decreased by insulin. Because

insulin secretion is sluggish in the neonatal period, glucagon may have a clinically significant effect on serum calcium concentration at this time. The frequency and severity of

hypocalcemia within the first 48 hr of life are increased by prematurity, perinatal trauma, hypoxia, and maternal diabetes (3,10). Functional hypoparathyroidism has been demonstrated in some

of these situations (3,10), but not all instances of hypocalcemia can be explained on this basis (3). Inasmuch as neonatal hypocalcemia is evidently a multifactorial disorder, all agents

capable of affecting calcium homeostasis deserve consideration. Glucagon can lower serum calcium concentration in a variety of mammals including man (2, 6–9, 11), but no studies of this

phenomenon in the neonatal period have been reported. Grajwer _el al._ (5) have pointed out that a large increase in immunoreactive plasma glucagon occurs within the first two hr after

delivery. Because the newborn infant is particularly susceptible to disturbances of calcium homeostasis, we designed the following experiments to test the effects of maturation on the

response of serum calcium concentration to exogenous glucagon. SIMILAR CONTENT BEING VIEWED BY OTHERS INTRAPERITONEAL AND SUBCUTANEOUS GLUCAGON DELIVERY IN ANAESTHETIZED PIGS: EFFECTS ON

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2021 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Perinatal Center and the Departments of Pediatrics and Obstetrics-Gynecology, State University of New York, Upstate Medical

Center, Syracuse, New York, USA Haim Elrad, W H Bergstrom & Turkan Dagoglu Authors * Haim Elrad View author publications You can also search for this author inPubMed Google Scholar * W H

Bergstrom View author publications You can also search for this author inPubMed Google Scholar * Turkan Dagoglu View author publications You can also search for this author inPubMed Google

Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Elrad, H., Bergstrom, W. & Dagoglu, T. Glucagon-induced Hypocalcemia in the Rat: Effects of

Maturation and Insulin. _Pediatr Res_ 14, 216–217 (1980). https://doi.org/10.1203/00006450-198003000-00007 Download citation * Issue Date: 01 March 1980 * DOI:

https://doi.org/10.1203/00006450-198003000-00007 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is

not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * glucagon * hypocalcemia * insulin