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ABSTRACT Splenectomized children are at increased risk of overwhelming pneumococcemia. Polyvalent pneumococcal vaccines may prevent these life-threatening infections since these patients

have a normal antibody response to pneumococcal vaccination (Giebink, et al, JID 141:404, 1980). To determine the persistence of antibody elevation, serum was obtained from 44 splenectomized

children 6 and 12 months after vaccination; 28 children had their spleens removed for traumatic splenic laceration, 11 for hereditary spherocytosis and 5 for Hodgkin's disease staging.

Four weeks after vaccination geometric mean antibody concentrations, measured by radioimmunoassay against 12 antigens contained in the vaccine, were 833, 1,113 and 477 ng antibody N/ml for

the traumatic, spherocytosis and Hodgkin's patients, respectively. Antibody levels after vaccination of 12 age-matched normal children and 6 children with hereditary spherocytosis with

intact spleens were 492 and 954 ng/ml, respectively. Rates of antibody decline in the splenectomized patients were linear, and one year after vaccination were 68.4%, 70.6% and 76.0% of the

peak post-vaccination antibody concentration in the three patient groups. None of the traumatic or spherocytosis patients had antibody levels less than 200 ng/ml one year after vaccination.

Two Hodgkin's patients had levels below 200 ng/ml. Since protective antibody levels are not known, periodic re-vaccination may be necessary in high-risk patients. ARTICLE PDF AUTHOR

INFORMATION AUTHORS AND AFFILIATIONS * Univ. of Minnesota School of Medicine, Minneapolis, and G. Schiffman, SUNY, Downstate Medical Center, Brooklyn G S Giebink Authors * G S Giebink View

author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Giebink, G. 918 SERUM

ANTIBODY DECLINE IN SPLENECTOHIZED CHILDREN AFTER PNEUMOCOCCAL VACCINATION. _Pediatr Res_ 15 (Suppl 4), 595 (1981). https://doi.org/10.1203/00006450-198104001-00943 Download citation * Issue

Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00943 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link

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