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ABSTRACT CO, tpH, and BL changes were studied in 8 puppies during acute hypovolemia and reinfusion . Hypovolemia was induced by bleeding 20 ml/kg of blood. Mean blood pressure (MBP),heart

rate (HR) and tpH were monitored continuously. CO, BL and arterial blood gases were analyzed every 15′ during the study. After 30′ hypovolemia blood was reinfused and all the above

parameters were monitored for the next 30′ cO, and tpH decreased significantly during hypovolemia. Changes in MBP were transient and minimal. The fall in tpH was greater than ApH (p<.05)

and its recovery slower than ApH. EL correlated better with tpH(r= −0.58, p<.005). Following reinfusion CO, HR, ApH returned to baseline but tpH lagged behind. Summary: 1) In acute

hypovolemia tpH was a better indicator of CO and peripheral metabolism than MBP. 2) Slow recovery of tpH following reinfusion could be due to slow clearance of tissue lactate. These data

indicate that tpH will be useful in detecting and treating impending or existing shock. (Data in M±S.E) ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * University of Illinois,

Dept. of Pediatrics, Chicago, Illinois Rama Bhat, Bert Braverman, Parvin Justice, Morton Schulman & Dharmapuri Vidyasagar Authors * Rama Bhat View author publications You can also search

for this author inPubMed Google Scholar * Bert Braverman View author publications You can also search for this author inPubMed Google Scholar * Parvin Justice View author publications You

can also search for this author inPubMed Google Scholar * Morton Schulman View author publications You can also search for this author inPubMed Google Scholar * Dharmapuri Vidyasagar View

author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bhat, R., Braverman, B.,

Justice, P. _et al._ 1252 TISSUE pH, (TpH), CARDIAC OUTPUT (CO)BLOOD LACTATE(BL) CHANGES FOLLOWING ACUTE HYPOVOLEMIA IN PUPPIES. _Pediatr Res_ 15 (Suppl 4), 651 (1981).

https://doi.org/10.1203/00006450-198104001-01279 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-01279 SHARE THIS ARTICLE Anyone you share the

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