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ABSTRACT The relationships of serum (Se) to Saliva (Sa) concentrations of Theophylline (Theo) and total methylxanthines (Mx) (Mx = Theo + Caffeine (Caf)) have been established in neonates

treated with Theo for apnea (J.Pediatr.96:494,1980). Serum to Sa relationships derived with additional studies have been crossvalidated against the old data. The standard deviations (SD) and

correlation coefficients (R) for the Se to Sa relationships are presented below. Data for Mx is presented because of Theo to Caf conversion in neonates. Crossvalidation results indicate

that R is high for Mx using both models and for Theo only for the ratio model. The discrepancy between Theo and Mx results may be caused by the wide interindividual differences in conversion

from Theo to Caf. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * So. IIlinois Univ. Sch. of Med., Depts. of Ped. and Pharmacol, and St. John's Hospital, Springfield, IL.

Narinder N Khanna, Satu M Somani, Ann Boyer, John E Miller, James A Menke, Carlos Chua & Joseph M Garfunkel Authors * Narinder N Khanna View author publications You can also search for

this author inPubMed Google Scholar * Satu M Somani View author publications You can also search for this author inPubMed Google Scholar * Ann Boyer View author publications You can also

search for this author inPubMed Google Scholar * John E Miller View author publications You can also search for this author inPubMed Google Scholar * James A Menke View author publications

You can also search for this author inPubMed Google Scholar * Carlos Chua View author publications You can also search for this author inPubMed Google Scholar * Joseph M Garfunkel View

author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Khanna, N., Somani, S.,

Boyer, A. _et al._ 341 CROSSVALIDATION OF SERUM TO SALIVA RELATIONSHIPS OF THEOPHYLLINE AND TOTAL METHYLXANTHINES IN NEONATES. _Pediatr Res_ 15 (Suppl 4), 497 (1981).

https://doi.org/10.1203/00006450-198104001-00352 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00352 SHARE THIS ARTICLE Anyone you share the

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