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ABSTRACT Because of the unavailability of alternate methods to determine protein-loss, we measured the gastrointestinal clearance of alpha-1-antitrypsin (AAT), by a modification of a

European technique. We studied eight patients, three with hypoalbuminemia and disorders suggestive of protein-losing enteropathy, and five with or without hypoalbuminemia and

gastrointestinal disorders not necessarily associated with protein loss. Clearance of AAT was calculated from the following equation: CAAT = (FxV)/P where C is in cc/days; F = fecal

concentration of AAT in cc/1; V = fecal volume in cc/day; P = serum AAT in mg/1. Stools were collected over a three day period and serum AAT obtained on each of three days and averaged in

some patients, and from two or one specimen in other patients. The stool was homogenized, and a one gram aliquot resuspended in distilled water. AAT was measured by radioimmuno-diffusion

using standard techniques. Serum AAT was measured by standard techniques. We conclude that a three day stool collection with determination of CAAT may be useful in identifying children with

protein losing enteropathy. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Yale Univ. School of Med., Dept. of Pediatrics, New Haven, CT B Grill, T Tinghitella, C Hilleraeier 

& J Gryboski Authors * B Grill View author publications You can also search for this author inPubMed Google Scholar * T Tinghitella View author publications You can also search for this

author inPubMed Google Scholar * C Hilleraeier View author publications You can also search for this author inPubMed Google Scholar * J Gryboski View author publications You can also search

for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Grill, B., Tinghitella, T., Hilleraeier, C. _et al._ 558

GASTROINTESTINAL CLEARANCE OF ALPHA-1-ANTITRYPSIN: A METHOD FOR DIAGNOSING PROTEIN-LOSING ENTEROPATHY. _Pediatr Res_ 15 (Suppl 4), 533 (1981).

https://doi.org/10.1203/00006450-198104001-00571 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00571 SHARE THIS ARTICLE Anyone you share the

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