Reader TTS

ABSTRACT 5 children (8.24+/-3.63 years) with growth retardation (3.4 +/-0.9 DS)bone age retardation (3.13+/-2.40 years) and insufficient growth velocity (3.9+/-0.6 cm/year) related with

complete (n=2) or partial (n=3) GH deficiency were treated with a daily dose of 300 mcg GRF administred subcutaneously (SC)every other week for a 6 months period. GH response to SC GRF

administration, GH and GRF antibodies and somatomedins were studied on repeated blood samples performed on day I and day 8 of the first week of treatment as well as at the end of the 6

months therapy. Growth velocity increased to 6.16+/-1.17 cm/year. 3 of the 5 patients have accelerated growth mainly for the first 3 months. Linear growth was increased in complete (+2.5 and

4.3 cm/year) more than in partial (+0.4, +0.8 and +3.3 cm/year) GH deficient children. The area under the GH curve after GRF administration was 1050.7+7-767.7 on day 1, 472.I+/-103.2 on day

8 and 631.9 +/-148.1 ng/ml x min. after 6 months therapy. No major change in other hormonal evaluations was noted. These results confirm that GRF can stimulate linear growth in some GH

deficient children and lead to discuss the role of limiting factors in its long term effects such as desensitization, antibodies or somatostatin. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * Institut R.B. GREENBLATT - BORDEAUX and SANOFI-RECHERCHE, MONTPELLIER, France M Colle, J Auzerie, M Morre & E Ruedas Authors * M Colle View author publications You can

also search for this author inPubMed Google Scholar * J Auzerie View author publications You can also search for this author inPubMed Google Scholar * M Morre View author publications You

can also search for this author inPubMed Google Scholar * E Ruedas View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Colle, M., Auzerie, J., Morre, M. _et al._ EFFECTS OF GROWTH-HORMONE - RELEASING HORMONE (GRF) IN 5 CHILDREN WITH IMPAIRED GROWTH HORMONE

(GH) SECRETION. _Pediatr Res_ 20, 1190 (1986). https://doi.org/10.1203/00006450-198611000-00100 Download citation * Issue Date: 01 November 1986 * DOI:

https://doi.org/10.1203/00006450-198611000-00100 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is

not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative