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ABSTRACT The classical criteria of birth asphyxia, low Apgar score and metabolic acidosis, correlate poorly with each other and with perinatal brain damage. We evaluated if hypoxanthine (HX)

and uric acid (UA) can be used as measures of the severity of asphyxia and/or predictors of adverse neurological outcome. We measured plasma HX and UA, as well as pH and lactate in

umbilical arterial blood of 62 infants born after severe preeclampsia of pregnancy (PP), 31 infants born acutely asphyxiated (AA) with 5-min Apgar <7 and/or pH ≤7.05, and 38 controls (C).

Follow-up was at 2 yr: severe brain damage was found in 4 PP and 5 AA infants, mild in 12 and 6. HX was higher in AA infants (geom mean; 95% conf: 24; 18-32 μmol/l), but not in PP

(10;9-11), than in C (12; 10-16). UA was higher in PP infants (mean; 95%conf: 430;398-46l μmol/l), but not in AA (336;288-385) than in C (303:282-324). In PP group HX did not correlate with

pH or lactate, whereas UA correlated with pH (r=-0.305, p=0.024) but not with lactate. In AA group HX correlated with pH (r=-0.647, p<0.001) and lactate (r=0.558, p=0.008), while UA

correlated with lactate (r=0.734, p<0.001) but not with pH. No correlation was found between HX or UA and outcome in either patient group. We conclude that cord HX is a measure of hypoxia

in acute asphyxia, but not in prolonged intrauterine distress (ie. PP), whereas the reverse is true for UA. Neither HX nor UA is a Dredictor of perinatal brain damage. ARTICLE PDF AUTHOR

INFORMATION AUTHORS AND AFFILIATIONS * Children's Hospital, University of Helsinki, Helsinki, Finland Vineta J Ruth & Kari O Raivio Authors * Vineta J Ruth View author publications

You can also search for this author inPubMed Google Scholar * Kari O Raivio View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS

Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ruth, V., Raivio, K. 128 PURINE METABOLITES AS MEASURES OF BIRTH ASPHYXIA AND PREDICTORS OF BRAIN DAMAGE. _Pediatr Res_ 24, 132

(1988). https://doi.org/10.1203/00006450-198807000-00152 Download citation * Issue Date: 01 July 1988 * DOI: https://doi.org/10.1203/00006450-198807000-00152 SHARE THIS ARTICLE Anyone you

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