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ABSTRACT ABSTRACT: We have determined if dietary protein restriction for 1 wk has differential effects on growth, serum IGF-I, and liver growth hormone receptors at various stages of

development. Female Wistar rats were fed a low (5%) protein diet for 7 d at 3, 4, 6, 8, and 12 wk of age, whereas controls were maintained on a normal (15%) protein diet. Body wt gain was

impaired in the groups fed the low protein diet, despite normal energy intake, and the effect was attenuated with age. Liver cell number (DNA content) was reduced by low protein feeding in

the 3-, 4-, and 6-wk age groups (_p_ < 0.01), but not in the older animals. Protein restriction caused a dramatic decrease in serum IGF-I in the younger animals (90 and 82% reduction

_versus_ normal fed age-matched controls, at 3 and 4 wk, respectively; _p_ < 0.001), and this effect was progressively attenuated with increasing age (49,40, and 25% reductions of serum

IGF-I at 6, 8, and 12 wk, respectively). Changes in serum IGF-I correlated with those of liver cell number (_r_ = 0.80; _p_ < 0.001). Total and free liver growth hormone receptors were

slightly decreased in the low protein diet groups at 4 (_p_ < 0.05) and 6 wk (total: _p_ < 0.001; free: _p_ < 0.01) but not in the other age groups. The occurrence of profound diet

induced reductions in IGF-I without proportional reductions in liver GH receptors suggest that the apparent GH resistance occurs at a postreceptor level. Because the degree of IGF-I

reduction correlates with the severity of retardation of liver growth during dietary protein restriction at different ages, we conclude that the effect of protein restriction on liver growth

could be mediated through IGF-I. SIMILAR CONTENT BEING VIEWED BY OTHERS SEVERE PROTEIN DEFICIENCY INDUCES HEPATIC EXPRESSION AND SYSTEMIC LEVEL OF FGF21 BUT INHIBITS ITS HYPOTHALAMIC

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AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Unite de Diabétologie et Nutrition, University of Louvain, Brussels, Belgium Therese Fliesen, Dominique Maiter, Marc Maes & Jean-Marie

Ketelslegers * Unite de Biométrie et Analyse des Données, University of Louvain, Brussels, Belgium Guy Gerard * Department of Pediatrics, Division of Pediatric Endocrinology, University of

North Carolina, Chapel Hill, 27599, North Carolina Louis E Underwood Authors * Therese Fliesen View author publications You can also search for this author inPubMed Google Scholar *

Dominique Maiter View author publications You can also search for this author inPubMed Google Scholar * Guy Gerard View author publications You can also search for this author inPubMed 

Google Scholar * Louis E Underwood View author publications You can also search for this author inPubMed Google Scholar * Marc Maes View author publications You can also search for this

author inPubMed Google Scholar * Jean-Marie Ketelslegers View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions

ABOUT THIS ARTICLE CITE THIS ARTICLE Fliesen, T., Maiter, D., Gerard, G. _et al._ Reduction of Serum Insulin-like Growth Factor-I by Dietary Protein Restriction Is Age Dependent. _Pediatr

Res_ 26, 415–419 (1989). https://doi.org/10.1203/00006450-198911000-00010 Download citation * Received: 21 February 1989 * Accepted: 20 June 1989 * Issue Date: 01 November 1989 * DOI:

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