Opiate infusions for preterm children?
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ABSTRACT Despite recent calls for the administration of opiates to ventilated newborn infants, there is a paucity of data to support their use. Single dose studies during surgery suggest
that commonly used drugs have a marked reduction in clearance. This study evaluates the use of a short acting synthetic opiod, alfentanil. 22 ventilated, paralysed preterm infants with
hyaline membrane disease (median BW:1348g (r:690-4084g); median GA:30 weeks (r:25-36w)) were given 20 micrograms/Kg alfentanil by slow intravenous injection over two minutes. Peak serum
concentration (med(r)) was 67ng/ml (13-606), clearance 0.9ml/min/kg (0.6-9.62) and elimination half life 321 mins (64-1251). Transient depression of BP and heart rate was noted. Using these
data in six children satisfactory serum levels of alfentanil were achieved using 20 micrograms/Kg over 30 mins followed by 5micrograms/Kg/hour with no cardiorespiratory effects. Further
studies are necessary to establish the efficacy of such treatment. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Child Health Liverpool Maternity Hospital,
Liverpool N Marlow, A M Weindling & R W I Cooke Authors * N Marlow View author publications You can also search for this author inPubMed Google Scholar * A M Weindling View author
publications You can also search for this author inPubMed Google Scholar * R W I Cooke View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND
PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Marlow, N., Weindling, A. & Cooke, R. OPIATE INFUSIONS FOR PRETERM CHILDREN?. _Pediatr Res_ 26, 522 (1989).
https://doi.org/10.1203/00006450-198911000-00139 Download citation * Issue Date: 01 November 1989 * DOI: https://doi.org/10.1203/00006450-198911000-00139 SHARE THIS ARTICLE Anyone you share
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