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ABSTRACT ABSTRACT: Pulsatile secretion of LH and FSH was examined in 10 prepubertal (aged 4.5–12.9 y) and seven early pubertal (aged 12.8–14.5 y) boys with ultrasensitive (0.019 and 0.014

IU/L time-resolved immunofluorometric assays. Plasma LH and FSH levels were measured every 15 or 20 min for 6 h during the day and night. The lowest mean LH level in a prepubertal boy was

0.02 IU/L and in eight other prepubertal boys mean LH levels were less than 0.4 IU/L. In early pubertal boys the mean LH levels ranged from 0.3 to 6.5 IU/L. The difference in mean FSH level

between prepubertal (0.61 IU/L) and early pubertal boys (1.85 IU/L) was smaller than the difference in LH level. All boys had significant LH and FSH pulses. The LH interpulse interval was

135 ± 86 min (mean ± SD) and 76 ± 65 min for the prepubertal and pubertal boys, respectively (_p_ < 0.01). For FSH, the respective values were 150 ± 122 and 221 ± 157 min (_p_ = NS). The

mean LH pulse amplitudes were 11-fold greater in the early pubertal boys than in the prepubertal boys, whereas the mean FSH pulse amplitudes were similar between the two groups. The present

method shows that the mean LH levels in prepubertal boys are much lower, and the increase during puberty larger, than previously reported. The increase is apparently due to increased pulse

frequency and amplitude. The increase in mean FSH level is smaller and evidently not caused by an increase in pulse frequency or pulse amplitude. SIMILAR CONTENT BEING VIEWED BY OTHERS NOVEL

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February 2021 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Children's Hospital, University of Helsinki, Oulu, Finland Leo Dunkel & Jaakko Perheentupa * Departments I

and II of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland Henrik Alfthan & Ulf-Hoakan Stenman * Department of Pediatrics, University of Oulu, Oulu, Finland Päivi

Tapanainen Authors * Leo Dunkel View author publications You can also search for this author inPubMed Google Scholar * Henrik Alfthan View author publications You can also search for this

author inPubMed Google Scholar * Ulf-Hoakan Stenman View author publications You can also search for this author inPubMed Google Scholar * Päivi Tapanainen View author publications You can

also search for this author inPubMed Google Scholar * Jaakko Perheentupa View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints

and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Dunkel, L., Alfthan, H., Stenman, UH. _et al._ Pulsatile Secretion of LH and FSH in Prepubertal and Early Pubertal Boys Revealed by

Ultrasensitive Time-Resolved Immunofluorometric Assays. _Pediatr Res_ 27, 215–219 (1990). https://doi.org/10.1203/00006450-199003000-00003 Download citation * Received: 31 July 1989 *

Accepted: 10 October 1989 * Issue Date: 01 March 1990 * DOI: https://doi.org/10.1203/00006450-199003000-00003 SHARE THIS ARTICLE Anyone you share the following link with will be able to read

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