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An increase in uteroplacental blood flow is required to supply oxygen and nutrients to the growing conceptus. However, mechanisms which enhance uterine vascular growth during gestation are

poorly understood. In the present study, pairs of uterine arteries from late-pregnant rabbits (n=6) were dissected - one fed a placenta (PL) and one fed the uterine wall (UT); structural and

functional differences compared. Arteries were mounted on two glass micro-cannula in a specialized arteriograph chamber that allowed for control over transmural pressure (TMP) and

measurement of lumen diameter. When TMP was increased step-wise from 25→125mmHg both artery types actively constricted and developed pressure-dependent tone, however, UT arteries had

significantly more tone than PL arteries over the entire pressure range:%tone@50, 75, 100, 125mmHg for PL vs. UT=20±4 vs. 29±5, 31±2 vs. 39±2, 36±2, vs. 42±2, 36±2, vs. 45±3;(p<0.01).

Under fully relaxed conditions (papaverine treated), the PL arteries were 26% larger than UT arteries: φPL=168±17μm vs. φUT=124±10μm (p<0.05), but were significantly less distensible @

TMP=25-125mmHg (p<0.05), indicating differences in both cellular growth and extra-cellular matrix remodeling of the vascular wall for the two vessel types. These structural differences

are likely to contribute to differential regulation of placental versus myoendometrial flow. These data also suggest that a localized factor(s) contributes to the greater gestational

enlargement of placental as compared to other uterine vessels. (NIH HL-44941) AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Oregon Health Sciences University, Portland, OR 97201 Marilyn J

Cipolla & Nancy Binder Authors * Marilyn J Cipolla View author publications You can also search for this author inPubMed Google Scholar * Nancy Binder View author publications You can

also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Cipolla, M., Binder, N. STRUCTURAL AND FUNCTIONAL

DIFFERENCES OF PLACENTAL COMPARED TO MYOENDOMETRIAL ARTERIES OF LATE GESTATION RABBITS. † 1193. _Pediatr Res_ 39 (Suppl 4), 201 (1996). https://doi.org/10.1203/00006450-199604001-01215

Download citation * Issue Date: 01 April 1996 * DOI: https://doi.org/10.1203/00006450-199604001-01215 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

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