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Viral injury, perticularlly secondary to adenovirus infection, may cause severe impairment of the respiratory tract in infants. This study was designed to evaluate the pulmonary function and

bronchodulator response in infants with clinical and virologic diagnosis of PCPD. 13 patients (M=5, F=8), mean age 1.32 years with a history of PCPD were included. Control group (CTRL),

included 13 patients (M=9, F=4), mean age 1.16 years. There were no significant differences in age or height between both groups. A Sensor Medics 2600 system was used. The parameters

assessed were. Respiratory Rate (RR), Peak Tidal Expiratory Flow (PTEF), Volume (%V-PF), and Time (Tme/Te) percentages for PTEF (T-PTEF) and PTEF/Tidal Volume ratio (PTEF/TV), Compliance

(Crs) and Resistance (Rrs) of respiratory system and Maximal Flow at Functional Residual Capacity (VmaxFRC). Bronchial responsiveness to inhaled ipatropium bromide (IB) 0.02 mg/kg and

albuterol (AL) 0.25 mg/kg were evaluated in the PCPD group on different days for all functional parameters. Results(x±SD) were as follows: Table VmaxFRC was obtained at 15, 30, 45 and 60

minutes after each nebulization. No differences were found with any of the bronchodilators. Parameters from the Tidal Flow/Volume Curves and Respiratory Mechanic were obtained at 45 minutes,

and their variations were not significant. We conclude that infants with PCPD have severe obstructive and restrictive disorders that are not modified by inhaled IB or AL adminitration.

AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Centro Respiratorio Hospital de Niños “R. Gutierrez”, Buenos Aires, Argentina A M Teper, C D Kofman, A F Maffey, S M Vidaurreta, J M Alduncir, M

Linares, G B Bayley & C N Macn Authors * A M Teper View author publications You can also search for this author inPubMed Google Scholar * C D Kofman View author publications You can

also search for this author inPubMed Google Scholar * A F Maffey View author publications You can also search for this author inPubMed Google Scholar * S M Vidaurreta View author

publications You can also search for this author inPubMed Google Scholar * J M Alduncir View author publications You can also search for this author inPubMed Google Scholar * M Linares View

author publications You can also search for this author inPubMed Google Scholar * G B Bayley View author publications You can also search for this author inPubMed Google Scholar * C N Macn

View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Teper, A., Kofman,

C., Maffey, A. _et al._ Pulmonary Function in Infants with Postviral Chronic Pulmonary Disease (PCPD). _Pediatr Res_ 39, 368 (1996). https://doi.org/10.1203/00006450-199602000-00031 Download

citation * Issue Date: 01 February 1996 * DOI: https://doi.org/10.1203/00006450-199602000-00031 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

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