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Access through your institution Buy or subscribe CD8+ T cells differentiate into different types of memory T cells after priming in the lymphoid organs. Central memory T cells selectively

express lymph node homing markers and recirculate between the blood and the secondary lymphoid organs. Effector memory T cells lack lymph node homing capacity, mainly circulate in the blood,

and may enter peripheral tissues. The third subset consists of tissue-resident memory T (Trm) cells that express CD69 and adhesion molecules such as CD11a, CD103, and CD49a that prevent

tissue egress. These Trm cells can be found throughout tissues and have important protective functions in infectious diseases as well as in malignancies. While it has been known for quite

some time that Trm cells form rapid local recall responses, more recent studies indicate that upon secondary infection, Trm cells can also return to the blood and differentiate into

circulating memory T-cell subsets [1, 2]. These studies indicate that Trm 1ells retain functional plasticity and that ex-Trm cells may contribute to systemic immunity. Trm populations of

skin, liver, small intestine, lungs, and other tissues are characterized by a specific set of transcription factors, including Runx3, Hobit, and Blimp-1, that control tissue exit [3].

Despite a common transcriptional signature, Trm cells in different tissues exhibit substantial diversity, as illustrated by the differential expression of certain surface receptors. CD103 is

highly expressed by Trm cells in skin, where this TGFβ-induced adhesion receptor mediates binding to epithelial-expressed E-cadherin [4]. In contrast, liver Trm cells do not express CD103

but instead upregulate CD11a, which is essential for lodgment into the sinusoidal endothelium. A recent paper by Mackay and coworkers has shed new light on the diversity of skin and liver

Trm cells and provides evidence that these Trm populations also have a different capacity to differentiate into circulating memory T cells [5]. This is a preview of subscription content,

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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Behr FM, Parga-Vidal L, Kragten NAM, van Dam TJP, Wesselink TH,

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defense against malaria liver-stage infection. Immunity. 2016;45:889–902. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of

Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066, CX, Amsterdam, The Netherlands Klaas P. J. M. van Gisbergen * Department of

Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands Joke

M. M. den Haan Authors * Klaas P. J. M. van Gisbergen View author publications You can also search for this author inPubMed Google Scholar * Joke M. M. den Haan View author publications You

can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Joke M. M. den Haan. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing

interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE van Gisbergen, K.P.J.M., den Haan, J.M.M. Staying home or leaving for a party:

tissue-dependent choices of tissue-resident memory T cells. _Cell Mol Immunol_ 19, 651–652 (2022). https://doi.org/10.1038/s41423-021-00828-z Download citation * Received: 09 December 2021 *

Accepted: 14 December 2021 * Published: 13 January 2022 * Issue Date: June 2022 * DOI: https://doi.org/10.1038/s41423-021-00828-z SHARE THIS ARTICLE Anyone you share the following link with

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