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ABSTRACT Studies have indicated that 25-hydroxyvitamin D (25(OH)D) level in obese is lower than normal weight subjects; however, results of studies that investigated relationship between

25(OH)D and fat mass are inconsistent. In addition, several randomized clinical trials (RCTs) have studied the influence of cholecalciferol supplement on percentage fat mass (PFM) but their

results are conflicting. The objectives were to investigate the association between vitamin D3 and PFM pooling together observational studies and RCTs. PubMed/MEDLINE, Cochrane, and Scopus

were comprehensively searched from inception to September 2016. The Fisher’s Z (SE) of correlation coefficient and mean (SD) of changes in PFM from baseline were used to perform

meta-analysis in observational studies and RCTs, respectively. To determine potential source of heterogeneity, subgroup and meta-regression analyses were conducted. Pooling correlation

coefficients showed an inverse association between PFM (Fisher’s _Z_: − 0.24, 95% CI: − 0.30 to −0 .18) and FM (Fisher’s _Z_: − 0.32, 95% CI: − 0.43 to − 0.22) and 25(OH)D. Subgroup analysis

revealed continent but not gender influence on the effect size. Meta-regression analysis indicated that age, latitude, and longitude are not sources of heterogeneity. Combining trials

showed vitamin D3 supplementation had a mild but insignificant effect on PFM (− 0.31%, 95% CI: − 1.07 to 0.44). Subgroup analyses indicated that type of cholecalciferol and treatment

regimens explain source of heterogeneity. Age, baseline body mass index, dose of cholecalciferol, length of study, female (%), and baseline 25(OH)D are not source of heterogeneity. In

conclusion, our results state that 25(OH)D level is inversely correlated with PFM but cholecalciferol supplementation had no effect on PFM. Access through your institution Buy or subscribe

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SERUM AND SUPPLEMENTAL VITAMIN D LEVELS AND INSULIN RESISTANCE IN T2DM POPULATIONS: A META-ANALYSIS AND SYSTEMATIC REVIEW Article Open access 31 July 2023 EFFECT OF CHOLECALCIFEROL VERSUS

CALCIFEDIOL ON SERUM 25(OH)D CONCENTRATIONS: A SYSTEMATIC REVIEW WITH META-ANALYSIS Article 09 October 2024 A DOSE–RESPONSE META-ANALYSIS BETWEEN SERUM CONCENTRATION OF 25-HYDROXY VITAMIN D

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Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mahdieh Golzarand & Parvin Mirmiran * Obesity Research Center, Research

Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mahdieh Golzarand & Parvin Mirmiran * Division of Neonatology, Department of Pediatrics,

Medical University of South Carolina, Charleston, SC, USA Bruce W. Hollis & Carol L. Wagner * Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran

University of Medical Sciences, Tehran, Iran Sakineh Shab-Bidar Authors * Mahdieh Golzarand View author publications You can also search for this author inPubMed Google Scholar * Bruce W.

Hollis View author publications You can also search for this author inPubMed Google Scholar * Parvin Mirmiran View author publications You can also search for this author inPubMed Google

Scholar * Carol L. Wagner View author publications You can also search for this author inPubMed Google Scholar * Sakineh Shab-Bidar View author publications You can also search for this

author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Sakineh Shab-Bidar. ETHICS DECLARATIONS CONFLICT OF INTEREST The authors declare that they have no conflict of interest.

ELECTRONIC SUPPLEMENTARY MATERIAL SUPPLEMENTARY TABLE 1(DOCX 13 KB) SUPPLEMENTARY TABLE 2(DOCX 11 KB) SUPPLEMENTARY TABLE 3(DOCX 26 KB) SUPPLEMENTARY FIGURE 1(DOCX 38 KB) SUPPLEMENTARY

FIGURE 2(DOCX 23 KB) SUPPLEMENTARY FIGURE 3(DOCX 38 KB) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Golzarand, M., Hollis, B.W., Mirmiran, P. _et

al._ Vitamin D supplementation and body fat mass: a systematic review and meta-analysis. _Eur J Clin Nutr_ 72, 1345–1357 (2018). https://doi.org/10.1038/s41430-018-0132-z Download citation *

Received: 14 July 2017 * Revised: 01 February 2018 * Accepted: 09 February 2018 * Published: 21 March 2018 * Issue Date: October 2018 * DOI: https://doi.org/10.1038/s41430-018-0132-z SHARE

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