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The significant discontinuation rate of available therapies and the paucity of curative options promoted the research on potential novel treatments suitable for erectile dysfunction

patients. The aim of this study was to provide a summary of available evidence regarding the news and future perspectives related to the non-surgical treatment of erectile dysfunction. A

narrative review of the literature was performed. A comprehensive search in the MEDLINE, Embase, and Scopus databases was done. Papers in English-language, published until April 2022, were

included. No chronological restriction was applied. Retrospective and prospective clinical studies, as well as meta-analyses, were considered. Oro-dispersible formulations of

phosphodiesterase type 5 inhibitors are particularly indicated in patients who have difficulty in swallowing solid dosage form; in addition, they constitute a discrete route of

administration not requiring water. Low-intensity extracorporeal shock wave therapy is indicated in mild vasculogenic erectile dysfunction and in patients with vasculogenic erectile

dysfunction poorly responsive to phosphodiesterase type 5 inhibitors. Stem cell therapy, platelet-rich plasma injections, and gene therapy seem promising regenerative treatments for selected

patients with erectile dysfunction. Novel oral formulations of drugs commonly used in erectile dysfunction patients have recently become part of standard clinical practice. Regenerative

treatments have been emerging in recent years and could become routine curative options in the near future. Further well-designed randomized controlled trials are needed to provide

conclusive evidence on this topic and guide appropriate recommendations.

A Correction to this paper has been published: https://doi.org/10.1038/s41443-022-00641-w

Salonia A, Bettocchi C, Carvalho J, Corona G, Jones TH, Kadioglu A, et al. European Association of Urology Guidelines on sexual and reproductive health. Presented at the EAU Annual Congress

Amsterdam. 2022. ISBN 978-94-92671-16-5.

Atallah S, Haydar A, Jabbour T, Kfoury P, Sader G. The effectiveness of psychological interventions alone, or in combination with phosphodiesterase-5 inhibitors, for the treatment of

erectile dysfunction: a systematic review. Arab J Urol. 2021;19:310–22.

Non-conditioning support of IBSA Institut Biochimique SA (Switzerland).

Urology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Naples, Italy

Department of Urology, University College London Hospitals NHS Trust, London, UK

Department of Urology, Copenhagen University Hospital—Herlev and Gentofte Hospital, Herlev, Denmark

Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

Department of Psychiatry, Centre of Postgraduate Medical Education, Warsaw, Poland

Endocrinology Unit, Medical Department, Maggiore-Bellaria Hospital, Bologna, Italy

CM drafting the manuscript; FC choice of topics and supervision; MF, MLS, CB, and JRO scientific and grammatical correction; GC critical review and final approval of the paper.

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

The original online version of this article was revised: The original version of this article unfortunately contained a mistake. The acknowledgements note was incorrect; the correct

acknowledgements note is given below. Acknowledgements Non-conditioning support of IBSA Institut Biochimique SA (Switzerland). The original article has been corrected.

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