Reader TTS

The fusion of an immunogenic peptide and the protein transthyretin protects the peptide antigen from proteolytic degradation, optimizes its uptake in local draining lymphatics and reduces

its presentation in uninflamed distal lymphoid organs, as shown in mice. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

institution ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $29.99 / 30 days cancel

any time Learn more Subscribe to this journal Receive 12 digital issues and online access to articles $119.00 per year only $9.92 per issue Learn more Buy this article * Purchase on

SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about

institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Rammensee, H. G., Falk, K. & Rotzschke, O. _Annu. Rev. Immunol._ 11, 213–244 (1993). Article  CAS 

Google Scholar  * Toes, R. E., Offringa, R., Blom, R. J., Melief, C. J. & Kast, W. M. _Proc. Natl Acad. Sci. USA_ 93, 7855–7860 (1996). Article  CAS  Google Scholar  * Mehta, N. K. et

al. _Nat. Biomed. Eng_. https://doi.org/10.1038/s41551-020-0563-4 (2020). * Francis, M. J. et al. _Proc. Natl Acad. Sci. USA_ 87, 2545–2549 (1990). Article  CAS  Google Scholar  * Janssen,

R. & Tommassen, J. _Int. Rev. Immunol._ 11, 113–121 (1994). Article  CAS  Google Scholar  * Suzue, K. & Young, R. A. _J. Immunol._ 156, 873–879 (1996). CAS  PubMed  Google Scholar  *

Mu, X. et al. _J. Virol. Methods_ 228, 84–90 (2016). Article  CAS  Google Scholar  * Botelho, N. K. et al. _Front. Immunol._ 10, 294 (2019). Article  CAS  Google Scholar  * Ishihara, J. et

al. _Sci. Transl. Med._ 9, eaan0401 (2017). Article  Google Scholar  * Wille-Reece, U. et al. _Proc. Natl Acad. Sci. USA_ 102, 15190–15194 (2005). Article  CAS  Google Scholar  * Zom, G. G.,

Khan, S., Filippov, D. V. & Ossendorp, F. _Adv. Immunol._ 114, 177–201 (2012). Article  CAS  Google Scholar  * Kim, S. et al. _Nat. Rev. Mater._ 4, 355–378 (2019). Article  Google

Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland Pedro Romero & Alena Donda *

Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA Jeffrey A. Hubbell Authors * Pedro Romero View author publications You can also search for this author

inPubMed Google Scholar * Alena Donda View author publications You can also search for this author inPubMed Google Scholar * Jeffrey A. Hubbell View author publications You can also search

for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Pedro Romero. ETHICS DECLARATIONS COMPETING INTERESTS P.R. is a member of the scientific advisory board of

immatics biotechnologies GmbH. J.A.H. is co-founder of Arrow Immune, Inc., and through his university holds patents in immuno-oncology. The remaining author declares no competing interests.

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Romero, P., Donda, A. & Hubbell, J.A. An optimized antigen–protein fusion. _Nat Biomed Eng_ 4,

583–584 (2020). https://doi.org/10.1038/s41551-020-0572-3 Download citation * Published: 12 June 2020 * Issue Date: June 2020 * DOI: https://doi.org/10.1038/s41551-020-0572-3 SHARE THIS

ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard

Provided by the Springer Nature SharedIt content-sharing initiative