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Post-translational histone modifications are important regulators of nuclear reprogramming. A study now reveals that histone lysine demethylase KDM4A-mediated H3K9me3 demethylation in

mammalian oocytes is essential for zygotic genome activation and preimplantation development. Access through your institution Buy or subscribe This is a preview of subscription content,

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institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Zhang, T., Cooper, S. & Brockdorff, N. _EMBO Rep._ 16, 1467–1481 (2015). Article  CAS  Google Scholar

  * Dahl, J. A. et al. _Nature_ 537, 548–552 (2016). Article  CAS  Google Scholar  * Zhang, B. et al. _Nature_ 537, 553–557 (2016). Article  CAS  Google Scholar  * Andreu-Vieyra, C. V. et

al. _PLoS Biol._ 8, e1000453 (2010). Article  Google Scholar  * Sankar, A. et al. _Development_ 144, 3264–3277 (2017). Article  CAS  Google Scholar  * Sankar, A. et al. _Nat. Cell Biol_.

https://doi.org/10.1038/s41556-020-0494-z (2020) * Huang, Y., Fang, J., Bedford, M. T., Zhang, Y. & Xu, R.-M. _Science_ 312, 748–751 (2006). Article  CAS  Google Scholar  * Pedersen, M.

T. et al. _EMBO J._ 35, 1550–1564 (2016). Article  CAS  Google Scholar  * Brind’Amour, J. et al. _Nat. Commun._ 9, 3331 (2018). Article  Google Scholar  * Eymery, A., Liu, Z., Ozonov, E. A.,

Stadler, M. B. & Peters, A. H. F. M. _Development_ 143, 2767–2779 (2016). Article  CAS  Google Scholar  * Xu, Q. et al. _Nat. Genet._ 51, 844–856 (2019). Article  CAS  Google Scholar  *

Hanna, C. W. et al. _Nat. Struct. Mol. Biol._ 25, 73–82 (2018). Article  CAS  Google Scholar  * Matsumura, Y. et al. _Mol. Cell_ 60, 584–596 (2015). Article  CAS  Google Scholar  * Groner,

A. C. et al. _PLoS Genet._ 6, e1000869 (2010). Article  Google Scholar  * Brumbaugh, J., Di Stefano, B. & Hochedlinger, K. _Development_ 146, dev182170 (2019). Article  CAS  Google

Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Medical Genetics, University of British Columbia, Life Sciences Institute, Vancouver, BC, Canada

Julie Brind’Amour & Matthew C. Lorincz Authors * Julie Brind’Amour View author publications You can also search for this author inPubMed Google Scholar * Matthew C. Lorincz View author

publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Matthew C. Lorincz. ETHICS DECLARATIONS COMPETING INTERESTS The authors

declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Brind’Amour, J., Lorincz, M.C. Setting the chromatin stage in oocytes.

_Nat Cell Biol_ 22, 355–357 (2020). https://doi.org/10.1038/s41556-020-0499-7 Download citation * Published: 30 March 2020 * Issue Date: April 2020 * DOI:

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