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Bivalent genes are regulated by a balance between repressive Polycomb group proteins and activating trithorax group proteins. A new study has revealed that MENIN, an accessory component of

KMT2A/B methyltransferase complexes, has an unorthodox role in repressing bivalent genes, alongside Polycomb repressive complexes. Access through your institution Buy or subscribe This is a

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Department of Biochemistry and Molecular Medicine, University of Southern California, Los Angeles, CA, USA Xue Qing David Wang & Yali Dou Authors * Xue Qing David Wang View author

publications You can also search for this author inPubMed Google Scholar * Yali Dou View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR

Correspondence to Yali Dou. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Wang, X.Q.D., Dou, Y. Dissecting MENIN in bivalent gene regulation. _Nat Cell Biol_ 25, 209–210 (2023). https://doi.org/10.1038/s41556-022-01063-y Download citation * Published: 12

January 2023 * Issue Date: February 2023 * DOI: https://doi.org/10.1038/s41556-022-01063-y SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

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