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Tight regulation of the activity of EWS–ETS fusion proteins is essential for the growth of Ewing sarcomas. Two new studies show that the transcriptional repressor ETV6 is essential for

tumour growth, acting to restrain fusion-protein-mediated gene activation, and revealing the importance of tissue-specific transcription factors to oncogenesis. Access through your

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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Sweet-Cordero, E. A. & Biegel, J. A.

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Seattle, WA, USA April A. Apfelbaum & Elizabeth R. Lawlor Authors * April A. Apfelbaum View author publications You can also search for this author inPubMed Google Scholar * Elizabeth R.

Lawlor View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Elizabeth R. Lawlor. ETHICS DECLARATIONS COMPETING

INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Apfelbaum, A.A., Lawlor, E.R. Oncogenic role for an

EWS–FLI1 suppressor. _Nat Cell Biol_ 25, 214–216 (2023). https://doi.org/10.1038/s41556-022-01067-8 Download citation * Published: 19 January 2023 * Issue Date: February 2023 * DOI:

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