Chaperoning RNA into granules | Nature Cell Biology
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Access through your institution Buy or subscribe Biomolecular condensate formation requires multivalent interactions and rapid turnover. Stress granules are condensates formed through
RNA–protein interactions under stress, requiring the RNA-binding protein G3BP. Parker et al. show that G3BP1 is an RNA condenser and promotes initial RNA–RNA interactions but is dispensable
for stability; instead, stability requires RNA–RNA interactions. The authors tested in vitro models of RNA granules and found that granules persisted despite proteinase digestion of G3BP1
only after sufficient ageing, or time, to form RNA–RNA interactions. RNA denaturation solubilized, whereas crosslinking stabilized, granules. The authors also suggest that RNA–RNA
interactions were intermolecular higher-order assemblies. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature
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AND AFFILIATIONS * Nature Cell Biology https://www.nature.com/ncb/ Daryl J. V. David Authors * Daryl J. V. David View author publications You can also search for this author inPubMed Google
Scholar CORRESPONDING AUTHOR Correspondence to Daryl J. V. David. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE David, D.J.V. Chaperoning RNA into
granules. _Nat Cell Biol_ 27, 4 (2025). https://doi.org/10.1038/s41556-024-01602-9 Download citation * Published: 16 January 2025 * Issue Date: January 2025 * DOI:
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