Feasibility of delaying coronary reperfusion

Feasibility of delaying coronary reperfusion


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A pilot study indicates that delaying reperfusion in ST-segment elevation myocardial infarction to allow enough time for mechanical unloading of the left ventricle (LV) to precondition the


myocardium and reduce injury is feasible within a short door-to-balloon time. Rates of major adverse cardiovascular and cerebrovascular events at 30 days in patients assigned to unloading of


the LV with the Impella CP device (Abiomed) followed by immediate reperfusion (_n_ = 25; door-to-balloon time 72 min) were similar to those in patients assigned to delayed reperfusion after


30 min of unloading (_n_ = 25; door-to-balloon time 97 min) (8% versus 12%), and delaying reperfusion did not affect 30-day mean infarct size. No major safety signals were identified that


would preclude a larger, pivotal trial. REFERENCES ORIGINAL ARTICLE * Kapur, N. K. et al. Unloading the left ventricle before reperfusion in patients with anterior ST-segment elevation


myocardial infarction: a pilot study using the Impella CP®. _Circulation_ https://doi.org/10.1161/CIRCULATIONAHA.118.038269 (2018) Article  PubMed  Google Scholar  Download references AUTHOR


INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Cardiology http://www.nature.com/nrcardio/ Irene Fernández-Ruiz Authors * Irene Fernández-Ruiz View author publications You can also


search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Irene Fernández-Ruiz. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS


ARTICLE Fernández-Ruiz, I. Feasibility of delaying coronary reperfusion. _Nat Rev Cardiol_ 16, 2 (2019). https://doi.org/10.1038/s41569-018-0127-4 Download citation * Published: 26 November


2018 * Issue Date: January 2019 * DOI: https://doi.org/10.1038/s41569-018-0127-4 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable


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