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Access through your institution Buy or subscribe Lung cancer has a high incidence worldwide and thus, population-based screening programmes have been proposed as a feasible approach to

improve the outcomes of patients with this disease. Now, the publication of 10-year follow-up results of the NELSON trial further informs this debate. On the basis of a questionnaire sent to

~600,000 individuals of 50–74 years of age, 15,792 respondents with a history of smoking were randomly assigned (1:1) to be part of the screening group (four rounds of low-dose CT screening

for lung cancer at baseline, 1, 3 and 5.5 years) or to the control group (no screening). Data on randomization date, sex, date of lung-cancer diagnosis, and date and cause of death were

obtained after approximately 5, 7 and 10–11 years of follow up. Among male participants, 6,583 were assigned to the screening group and 6,612 to the control group. The average screening

uptake was 90.0%, with 22,600 CT scans performed (9.2% of which needed to be repeated). A positive result was obtained in 467 CT scans (2.1%), subsequently resulting in 203

screening-detected lung cancers. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature

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calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * de Koning,

H. J. et al. Reduced lung-cancer mortality with volume CT screening in a randomized trial. _N. Engl. J. Med._ 382, 503–513 (2020) Article  Google Scholar  Download references AUTHOR

INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Clinical Oncology http://www.nature.com/nrclinonc Diana Romero Authors * Diana Romero View author publications You can also search for

this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Diana Romero. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Romero, D.

NELSON updated. _Nat Rev Clin Oncol_ 17, 197 (2020). https://doi.org/10.1038/s41571-020-0342-x Download citation * Published: 14 February 2020 * Issue Date: April 2020 * DOI:

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