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The causes of type 1 diabetes mellitus (T1DM) are unclear; however, a general consensus exists that T1DM is a T cell-mediated autoimmune disease characterized by the selective destruction of

insulin-secreting β-cells. Now, two imaging mass cytometry studies of human pancreatic tissue illuminate new biology in the pathogenesis of T1DM. Access through your institution Buy or

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ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Damond, N. K. et al. A map of human type 1 diabetes

progression by imaging mass cytometry. _Cell Metab._ https://doi.org/10.1016/j.cmet.2018.11.014 (2019). Article  PubMed  PubMed Central  Google Scholar  * Wang, Y. J. et al. Multiplexed in

situ imaging mass cytometry analysis of the human endocrine pancreas and immune system in type 1 diabetes. _Cell Metab._ https://doi.org/10.1016/j.cmet.2019.01.003 (2019). Article  PubMed 

PubMed Central  Google Scholar  * Gepts, W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. _Diabetes_ 14, 619–633 (1965). Article  CAS  Google Scholar  * Foulis, A. K.

& Stewart, J. A. The pancreas in recent-onset type 1 (insulin- dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine acinar tissue.

_Diabetologia_ 26, 456–461 (1984). Article  CAS  Google Scholar  * Rui, J. et al. B cells that resist immunological attack develop during progression of autoimmune diabetes in NOD mice.

_Cell Metab._ 25, 727–738 (2017). Article  CAS  Google Scholar  * Signore, A. et al. Detection of insulitis by pancreatic scintigraphy with 99mTc-labeled IL-2 and MRI in patients with LADA

(Action LADA 10). _Diabetes Care_ 38, 652–658 (2015). CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Unit of Endocrinology and Diabetes,

University Campus Bio-Medico, Rome, Italy Paolo Pozzilli * Centre of Immunobiology, Blizard Institute, Queen Mary, University of London, London, UK Paolo Pozzilli * Nuclear Medicine Unit,

Department of Medical-Surgical Sciences and of Translational Medicine, “Sapienza” University of Rome, Rome, Italy Alberto Signore Authors * Paolo Pozzilli View author publications You can

also search for this author inPubMed Google Scholar * Alberto Signore View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS The authors

contributed equally to all aspects of the article. CORRESPONDING AUTHOR Correspondence to Paolo Pozzilli. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests.

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Pozzilli, P., Signore, A. The reconstructed natural history of type 1 diabetes mellitus. _Nat Rev

Endocrinol_ 15, 256–257 (2019). https://doi.org/10.1038/s41574-019-0192-8 Download citation * Published: 11 March 2019 * Issue Date: May 2019 * DOI: https://doi.org/10.1038/s41574-019-0192-8

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