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Access through your institution Buy or subscribe Anaplastic thyroid carcinoma (ATC) is a rare form of undifferentiated thyroid cancer that is treatment-resistant and has high mortality. A

new study in _Thyroid_ identifies signalling pathways that have important roles in the function of ATC cancer stem cells. “To screen for important intracellular signalling pathways, we used

an siRNA library to selectively knock down 719 kinases [in cells derived from human ATCs] and observed sphere-forming abilities, which reflects cancer stem cell ability,” explains

corresponding author Norisato Mitsutake. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other

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are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE *

Shiraiwa, K. et al. The JAK/STAT3 and NF-κB signaling pathways regulate cancer stem cell properties in anaplastic thyroid cancer cells. _Thyroid_ https://doi.org/10.1089/thy.2018.0212 (2019)

Article  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Endocrinology http://www.nature.com/nrendo/ Shimona Starling Authors *

Shimona Starling View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Shimona Starling. RIGHTS AND PERMISSIONS Reprints

and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Starling, S. Key pathways revealed in rare thyroid cancer. _Nat Rev Endocrinol_ 15, 254–255 (2019).

https://doi.org/10.1038/s41574-019-0193-7 Download citation * Published: 13 March 2019 * Issue Date: May 2019 * DOI: https://doi.org/10.1038/s41574-019-0193-7 SHARE THIS ARTICLE Anyone you

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