DNA Typewriter | Nature Reviews Genetics
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DNA-based recording technologies are engineered systems that record molecular events as permanent changes in a cell’s genome. Although a promising approach to track biological events in
living cells, existing ‘DNA memory’ devices are restricted in terms of the number of distinct signals that can be recorded and their inability to record the order of signals. A recent study
in Nature describes ‘DNA Typewriter’, a prime-editing-based DNA recorder that can capture the order of large numbers of distinct events in mammalian cells.
Using DNA Tape (TAPE-1) amenable to prime editing by the enzyme PE2 and a set of 16 pegRNAs that insert unique 2-bp barcodes in HEK293T cells, Choi et al. observed sequential editing of
target sites, although editing rates were modest (~5%).
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