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Access through your institution Buy or subscribe Bacterial persisters, which are a subpopulation of transiently antibiotic-tolerant bacterial cells that are slow-growing or growth-arrested,

can cause persistent infections. Under laboratory conditions, persisters seem to become dormant; however, Helaine and colleagues show that in the non-growing, antibiotic-tolerant state,

_Salmonella enterica_ subsp. _enterica_ serovar Typhimurium actively subverts host cells. During macrophage infection, _S_. Typhimurium antibiotic persisters retain transcriptional,

translational and metabolic activity. Moreover, non-growing _S_. Typhimurium translocates _Salmonella_ pathogenicity island 2 (SPI-2) type III secretion system effectors into the macrophage

to reprogramme the host cell into a non-inflammatory and infection-permissive state. Thus, the active, non-growing state promotes survival during antibiotic exposure, persistent infections

and long-term survival. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio

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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Stapels, D. A. C. &

Hill, P. W. S. et al. Salmonella persisters undermine host immune defenses during antibiotic treatment. _Science_ 362, 1156–1160 (2018) Article  CAS  Google Scholar  FURTHER READING *

Fisher, R. A., Gollan, B. & Helaine, S. Persistent bacterial infections and persister cells. _Nat. Rev. Microbiol._ 15, 453–464 (2017) Article  CAS  Google Scholar  Download references

AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Microbiology http://www.nature.com/nrmicro/ Andrea Du Toit Authors * Andrea Du Toit View author publications You can also search

for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Andrea Du Toit. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Du Toit,

A. Reprogramming by persisters. _Nat Rev Microbiol_ 17, 65 (2019). https://doi.org/10.1038/s41579-018-0143-8 Download citation * Published: 18 December 2018 * Issue Date: February 2019 *

DOI: https://doi.org/10.1038/s41579-018-0143-8 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is

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