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Access through your institution Buy or subscribe Many pathogenic bacteria suppress epithelial exfoliation (rapid shedding of cells) to enhance host colonization. Common to these pathogens is

their ability to bind carcinoembryonic antigen-related cell adhesion molecules (CEACAMs). _Neisseria gonorrhoeae_ binding to CEACAM upregulates the expression of _CD105_, which is necessary

to suppress exfoliation. Muenzner and Hauck find that CEACAM engagement by _N. gonorrhoeae_ in mice leads to the release of nitric oxide (NO) by the bacteria, which initiates a protein

kinase G-dependent signalling cascade in the host that upregulates _CD105_ expression, leading to suppression of exfoliation. Blockade of this pathway led to the re-establishment of

exfoliation, which inhibited _N. gonorrhoeae_ vaginal colonization in mice, suggesting that targeting this pathway could be a promising treatment strategy. This is a preview of subscription

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Muenzner, P. & Hauck, C. R. _Neisseria gonorrhoeae_ blocks epithelial

exfoliation by nitric-oxide-mediated metabolic cross talk to promote colonization in mice. _Cell Host Microbe_ https://doi.org/10.1016/j.chom.2020.03.010 (2020) Article  PubMed  Google

Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Microbiology http://www.nature.com/nrmicro/ Ashley York Authors * Ashley York View author

publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Ashley York. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE York, A. Exfoliating _Neisseria gonorrhoeae_. _Nat Rev Microbiol_ 18, 317 (2020). https://doi.org/10.1038/s41579-020-0375-2 Download citation * Published: 21 April

2020 * Issue Date: June 2020 * DOI: https://doi.org/10.1038/s41579-020-0375-2 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable

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