Reader TTS

Human ageing trajectories are highly individual and dependent on genetic and non-genetic factors. An analysis of the interconnectivity of distinct age-related chronic diseases shows that

organ-specific chronic diseases accelerate the ageing of other organ systems, which has important implications for mortality. Notably, chronic kidney disease was identified a highly

important risk factor for the ageing of other organ systems. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS

OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $29.99 / 30 days cancel any time Learn

more Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to

full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our

FAQs * Contact customer support REFERENCES * Ferrucci, L. et al. Measuring biological aging in humans: a quest. _Aging Cell_ 19, e13080 (2020). Article  CAS  PubMed  Google Scholar  *

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. The hallmarks of aging. _Cell_ 153, 1194–1217 (2013). Article  PubMed  PubMed Central  Google Scholar  * Tian, Y.

E. et al. Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality. _Nat. Med._ https://doi.org/10.1038/s41591-023-02296-6 (2023). Article  PubMed 

PubMed Central  Google Scholar  * Benzing, T. & Salant, D. Insights into glomerular filtration and albuminuria. _N. Engl. J. Med._ 384, 1437–1446 (2021). Article  CAS  PubMed  Google

Scholar  * Hallan, S. I. et al. Age and association of kidney measures with mortality and end-stage renal disease. _J. Am. Med. Assoc._ 308, 2349–2360 (2012). Article  CAS  Google Scholar  *

Fontana, L. & Partridge, L. Promoting health and longevity through diet: from model organisms to humans. _Cell_ 161, 106–118 (2015). Article  CAS  PubMed  PubMed Central  Google Scholar

  * Horvath, S. DNA methylation age of human tissues and cell types. _Genome Biol._ 14, R115 (2013). Article  PubMed  PubMed Central  Google Scholar  * Zhu, T., Zheng, S. C., Paul, D. S.,

Horvath, S. & Teschendorff, A. E. Cell and tissue type independent age-associated DNA methylation changes are not rare but common. _Aging_ 10, 3541–3557 (2018). Article  PubMed  PubMed

Central  Google Scholar  * Belsky, D. W. et al. Quantification of biological aging in young adults. _Proc. Natl Acad. Sci. USA_ 112, E4104–E4110 (2015). Article  CAS  PubMed  PubMed Central

  Google Scholar  * López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Hallmarks of aging: an expanding universe. _Cell_ 186, 243–278 (2023). Article  PubMed  Google

Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department II of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne,

Cologne, Germany Thomas Benzing * Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of

Cologne, Cologne, Germany Thomas Benzing & Björn Schumacher * Institute for Genome Stability in Aging and Disease, Medical Faculty, University and University Hospital of Cologne,

Cologne, Germany Björn Schumacher Authors * Thomas Benzing View author publications You can also search for this author inPubMed Google Scholar * Björn Schumacher View author publications

You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Thomas Benzing. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing

interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Benzing, T., Schumacher, B. Chronic kidney disease promotes ageing in a multiorgan disease

network. _Nat Rev Nephrol_ 19, 542–543 (2023). https://doi.org/10.1038/s41581-023-00729-6 Download citation * Published: 26 May 2023 * Issue Date: September 2023 * DOI:

https://doi.org/10.1038/s41581-023-00729-6 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not

currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative