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Access through your institution Buy or subscribe The spectrum of hyperferritinaemic syndrome encompasses clinical conditions including adult-onset Still disease (AOSD), macrophage activation

syndrome, catastrophic anti-phospholipid syndrome and septic shock, as well as severe COVID-19. Emerging evidence suggests that ferritin, rather than being a biomarker of the inflammatory

response, might contribute directly to the pathogenic mechanism that results in systemic inflammation. A study now shows that ferritin promotes neutrophil activation and the formation of

neutrophil extracellular traps (NETs) via the ferritin receptor macrophage scavenger receptor 1 (MSR1), and highlights the therapeutic potential of targeting this pathway. In the study, mice

treated with intraperitoneally administered ferritin developed systemic inflammation, characterized by a cytokine storm, as well as hepatic inflammation, with increased recruitment of

neutrophils and markers of NET formation evident in liver tissue. Further investigations established that neutrophils are essential for ferritin-induced inflammation, and that

peptidylarginine deiminase 4, neutrophil elastase and reactive oxygen species are indispensable for NET formation. This is a preview of subscription content, access via your institution

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FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Jia, J. et al. Ferritin triggers neutrophil extracellular trap-mediated cytokine storm through Msr1 contributing to adult-onset

Still’s disease pathogenesis. _Nat. Commun._ 13, 6804 (2022) Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Rheumatology

http://www.nature.com/nrrheum/ Sarah Onuora Authors * Sarah Onuora View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to

Sarah Onuora. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Onuora, S. Ferritin-induced NETs lead to cytokine storm in AOSD. _Nat Rev Rheumatol_ 19,

61 (2023). https://doi.org/10.1038/s41584-022-00899-w Download citation * Published: 04 January 2023 * Issue Date: February 2023 * DOI: https://doi.org/10.1038/s41584-022-00899-w SHARE THIS

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