Reader TTS

Viral mRNA synthesis is an essential step in the influenza virus replication cycle and is a prime target for the development of new antivirals. New structures of the influenza virus RNA

polymerase now unveil previously unknown details of influenza virus transcription. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

institution ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $29.99 / 30 days

cancel any time Learn more Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink *

Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional

subscriptions * Read our FAQs * Contact customer support REFERENCES * Krug, R. M., Morgan, M. A. & Shatkin, A. J. _J. Virol._ 20, 45–53 (1976). CAS  PubMed  PubMed Central  Google

Scholar  * Etkind, P. R. & Krug, R. M. _Virology_ 62, 38–45 (1974). Article  CAS  PubMed  Google Scholar  * Decroly, E. & Canard, B. _Curr. Opin. Virol._ 24, 87–96 (2017). Article 

CAS  PubMed  PubMed Central  Google Scholar  * Plotch, S. J., Bouloy, M., Ulmanen, I. & Krug, R. M. _Cell_ 23, 847–858 (1981). Article  CAS  PubMed  Google Scholar  * Kouba, T., Drncova,

P. & Cusack, S. _Nat. Struct. Mol. Biol_. https://doi.org/10.1038/s41594-019-0232-z (2019). * Lukarska, M. et al. _Nature_ 541, 117–121 (2017). Article  CAS  PubMed  Google Scholar  *

Serna Martin, I. et al. _Mol. Cell_ 70, 1101–1110.e4 (2018). Article  CAS  PubMed  PubMed Central  Google Scholar  * Reich, S. et al. _Nature_ 516, 361–366 (2014). Article  CAS  PubMed 

Google Scholar  * Koppstein, D., Ashour, J. & Bartel, D. P. _Nucleic Acids Res._ 43, 5052–5064 (2015). Article  CAS  PubMed  PubMed Central  Google Scholar  * Reich, S., Guilligay, D.

& Cusack, S. _Nucleic Acids Res._ 45, 3353–3368 (2017). CAS  PubMed  PubMed Central  Google Scholar  * Robb, N. C. et al. _Nucleic Acids Res._ 44, 10304–10315 (2016). CAS  PubMed  PubMed

Central  Google Scholar  * Robb, N., te Velthuis, A.J.W., Fodor, E. & Kapanidis, A.N. _Nucleic Acids Res_. https://doi.org/10.1093/nar/gkz313 (2019). * Pauly, M. D., Procario, M. C.

& Lauring, A. S. _eLife_ 6, e26437 (2017). Article  PubMed  PubMed Central  Google Scholar  * Goldhill, D. H. et al. _Proc. Natl Acad. Sci. USA_ 115, 11613–11618 (2018). Article  CAS 

PubMed  PubMed Central  Google Scholar  * te Velthuis, A. J. W., Robb, N. C., Kapanidis, A. N. & Fodor, E. _Nat. Microbiol._ 1, 16029 (2016). Article  Google Scholar  * Appleby, T. C. et

al. _Science_ 347, 771–775 (2015). Article  CAS  PubMed  Google Scholar  * Laurila, M. R. L., Makeyev, E. V. & Bamford, D. H. _J. Biol. Chem._ 277, 17117–17124 (2002). Article  CAS 

PubMed  Google Scholar  * Klumpp, K., Ford, M. J. & Ruigrok, R. W. _J. Gen. Virol._ 79, 1033–1045 (1998). Article  CAS  PubMed  Google Scholar  * Braam, J., Ulmanen, I. & Krug, R. M.

_Cell_ 34, 609–618 (1983). Article  CAS  PubMed  Google Scholar  * Te Velthuis, A. J. W. et al. _Nat. Microbiol._ 3, 1234–1242 (2018). Article  Google Scholar  Download references

ACKNOWLEDGEMENTS A.J.W.t.V. is supported by joint Wellcome Trust and Royal Society grant 206579/Z/17/Z and Isaac Newton Trust grant 17.37(r). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

University of Cambridge, Department of Pathology, Addenbrooke’s Hospital, Cambridge, UK Aartjan J. W. te Velthuis Authors * Aartjan J. W. te Velthuis View author publications You can also

search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Aartjan J. W. te Velthuis. ETHICS DECLARATIONS COMPETING INTERESTS The author declares no competing

interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE te Velthuis, A.J.W. Flu transcription captured in action. _Nat Struct Mol Biol_ 26, 393–395

(2019). https://doi.org/10.1038/s41594-019-0243-9 Download citation * Published: 03 June 2019 * Issue Date: June 2019 * DOI: https://doi.org/10.1038/s41594-019-0243-9 SHARE THIS ARTICLE

Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided

by the Springer Nature SharedIt content-sharing initiative