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The mitochondrial unfolded protein response (UPRmt) is a transcriptional program that is activated in cells experiencing mitochondrial stress and that helps to return to proteostasis and

improve stress resistance. Ying et al. reveal that the UPRmt controls the mesenchymal-to-epithelial transition during the acquisition of pluripotency. Access through your institution Buy or

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checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Martinus, R. D. et al. _Eur. J. Biochem._ 240,

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Biology, Department of Nutritional Sciences & Toxicology, University of California, Berkeley, CA, USA Marine Barthez & Danica Chen Authors * Marine Barthez View author publications

You can also search for this author inPubMed Google Scholar * Danica Chen View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR

Correspondence to Danica Chen. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE

THIS ARTICLE Barthez, M., Chen, D. UPRmt controls the mesenchymal-to-epithelial transition. _Nat Metab_ 7, 871–872 (2025). https://doi.org/10.1038/s42255-025-01260-7 Download citation *

Published: 09 April 2025 * Issue Date: May 2025 * DOI: https://doi.org/10.1038/s42255-025-01260-7 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

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