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A key consequence of increased and sustained vascular permeability in several inflammatory and cardiovascular disorders is the development of interstitial protein-rich proinflammatory edema.

This response remains poorly understood mechanistically and its potential adverse effect on local and systemic diseases is often underestimated. To discuss current findings and identify

crucial unresolved questions, a workshop was held in Berlin from 12–15 April 2023. Key topics that were discussed included regulation of endothelial cell junctions, neutrophil-dependent

vascular leakage, resolution of edema, exemplar diseases, and anti-edema therapies. This report is a summary of the meeting. Access through your institution Buy or subscribe This is a

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calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Claesson-Welsh, L., Dejana,

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indebted to the Berlin Permeability workshop participants for their presentations and discussions and apologize to authors whose work we have not cited due to space restrictions. The

contributions from the Max-Planck Society for the arrangements of the workshop are gratefully acknowledged. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Vascular Cell Biology,

Max-Planck Institute for Molecular Biomedicine, Münster, Germany Dietmar Vestweber * Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Lena

Claesson-Welsh * Department of Anatomy, Cardiovascular Research Institute, and UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA Donald

M. McDonald * National Heart & Lung Institute, Imperial College London, London, UK Timothy Williams * Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven,

CT, USA Martin A. Schwartz & Michael Simons * Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, USA Joshua Scallan * Department of Life

Sciences, Brunel University London, London, UK Felicity N. E. Gavins * Faculty of Science Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands Jaap van

Buul * Centenary Institute, University of Sydney, Sydney, New South Wales, Australia Jennifer Gamble & Matthew Vadas * The Heart Research Institute, Newtown, New South Wales, Australia

Matthew Vadas * Department of Medicine, Medical College of Georgia, Augusta, GA, USA Brian H. Annex * Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA, USA

Steven R. Messe * William Harvey Research Institute, Queen Mary University of London, London, UK Mauro Perretti & Sussan Nourshargh * Department of Clinical Neuroscience, Karolinska

Institute, Stockholm, Sweden Helder André * Department of Pathology, University of California San Diego, San Diego, CA, USA Napoleone Ferrara * Department of Surgery, Boston Children’s

Hospital, Harvard Medical School, Boston, MA, USA Timothy Hla Authors * Dietmar Vestweber View author publications You can also search for this author inPubMed Google Scholar * Lena

Claesson-Welsh View author publications You can also search for this author inPubMed Google Scholar * Donald M. McDonald View author publications You can also search for this author inPubMed

 Google Scholar * Timothy Williams View author publications You can also search for this author inPubMed Google Scholar * Martin A. Schwartz View author publications You can also search for

this author inPubMed Google Scholar * Joshua Scallan View author publications You can also search for this author inPubMed Google Scholar * Felicity N. E. Gavins View author publications You

can also search for this author inPubMed Google Scholar * Jaap van Buul View author publications You can also search for this author inPubMed Google Scholar * Jennifer Gamble View author

publications You can also search for this author inPubMed Google Scholar * Matthew Vadas View author publications You can also search for this author inPubMed Google Scholar * Brian H. Annex

View author publications You can also search for this author inPubMed Google Scholar * Steven R. Messe View author publications You can also search for this author inPubMed Google Scholar *

Mauro Perretti View author publications You can also search for this author inPubMed Google Scholar * Helder André View author publications You can also search for this author inPubMed 

Google Scholar * Napoleone Ferrara View author publications You can also search for this author inPubMed Google Scholar * Timothy Hla View author publications You can also search for this

author inPubMed Google Scholar * Sussan Nourshargh View author publications You can also search for this author inPubMed Google Scholar * Michael Simons View author publications You can also

search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Dietmar Vestweber or Michael Simons. ETHICS DECLARATIONS COMPETING INTERESTS M.S. is a founder and SAB

member of VST Bio, Inc. S.R.M. is a consultant to VST Bio, Inc. The other authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE

THIS ARTICLE Vestweber, D., Claesson-Welsh, L., McDonald, D.M. _et al._ Report from the 2023 workshop on endothelial permeability, edema and inflammation. _Nat Cardiovasc Res_ 2, 1120–1124

(2023). https://doi.org/10.1038/s44161-023-00385-w Download citation * Published: 08 December 2023 * Issue Date: December 2023 * DOI: https://doi.org/10.1038/s44161-023-00385-w SHARE THIS

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