Nature immunology - volume 3 issue 1, january 2002
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Dendritic cells activated by lipopolysaccharide (left) initiate inflammatory responses. A complex series of intracellular cues leads to dynamic changes in the structure of the cell's
DNA and to the transcription of various chemokine and cytokines. Saccani _et al._ on page 69 report that, in dendritic cells, the kinase p38 ensures that histone H3, in the promoters of a
particular set of genes, gets phosphorylated, preparing the site for transcription. Original light micrograph by Saccani et al.