
Statins: Side effects may be down to the 'nocebo effect', research shows
- Select a language for the TTS:
- UK English Female
- UK English Male
- US English Female
- US English Male
- Australian Female
- Australian Male
- Language selected: (auto detect) - EN
Play all audios:

When it comes to helping their patients, many GPs favour statins as they can reduce "bad" cholesterol levels by up to 50 percent. If cholesterol is allowed to build up in the body, blood
pressure increases and the risk of having a life-threatening incident increases. The life-saving tool doesn't work for everybody, as "many patients are not able to take statins because of
side effects such as muscle pain, called myalgia," said PHD fellow at Imperial College London, James Philip Howard. However, his recent research highlights many side effects attributed to
statins by his study participants were also experienced when taking dummy pills.
The 12-month trial consisted of 60 people who were given 12 medication jars each at the beginning of the experiment.
All of the participants had previously taken one or more statins in the past, but had stopped taking them due to side effects.
At the beginning of each month, the participants opened a new jar without knowing if the jar contained statins or placebos.
READ MORE: Statins side effects - why you should avoid grapefruit in your diet while taking statins
Study participants tracked the intensity of their symptoms daily on a smart phone.
The side effects were ranked on a scale from zero ("no symptoms") to 100 ("worst imaginable" symptoms).
The participants could stop the tablets for the month if the symptoms became intolerable.
Researcher Howard said: "We were surprised how severe some of the symptoms experienced during the study were.
DON'T MISSApple cider vinegar: The 17 lesser-known health benefits [INSIGHT]Covid treatment: Major boost in drugs treating virus [ADVICE]Diabetes symptoms: The signs in you legs [TIPS]
We use your sign-up to provide content in ways you've consented to and to improve our understanding of you. This may include adverts from us and 3rd parties based on our understanding. You
can unsubscribe at any time. Read our Privacy Policy
"Twenty-four patients, on 71 occasions, had symptoms so severe they had to stop taking their tablets temporarily.
"However, this occurred just as frequently when patients took a placebo as when they took a statin.”
Dr Howard proposed these side effects were mostly caused by the "nocebo effect".
This is when people experience side effects from statins, for example, because of their negative association with the medicine.
The psychological discomfort created has little, if anything, to do with the actual pharmacological effect of the drug.
Dr Howard emphasised: "Patients should be taken seriously when they report side effects, because they are genuinely suffering."
As a co-author of the study, Howard and his colleagues suggest that patients should be informed of the nocebo effect when prescribed statins.
He added that "some of the side effects could also be from the typical aches and pains of getting older".
Dr Howard concluded: "Our findings are significant because they are further evidence that side effects from statins are minimal.
"These drugs play a significant role in keeping patients who are at risk of cardiovascular disease healthy."
Previous research suggests that statins can reduce the risk of a heart attack, stroke, and even death by up to 35 percent.
The study was funded by the British Heart Foundation and is published in the New England Journal of Medicine.
See today's front and back pages, download the newspaper, order back issues and use the historic Daily Express newspaper archive.