[3h]paroxetine and [3h]citalopram as markers of the human brain 5-ht uptake site
- Select a language for the TTS:
- UK English Female
- UK English Male
- US English Female
- US English Male
- Australian Female
- Australian Male
- Language selected: (auto detect) - EN
Play all audios:
ABSTRACT The binding of [3H]paroxetine and [3H]citalopram to the brain serotonin (5-HT) uptake site was characterized and compared in human hypothalamus, frontal cortex and caudate nucleus.
Our results showed that the binding exclusively related to the 5-HT uptake site (specific or 5-HT displaceable binding) was identical for both [3H]ligands. The selective 5-HT uptake
inhibitor citalopram displayed the highest potency (Ki) in inhibiting the [3H]paroxetine and [3H]citalopram binding, as compared with the values obtained for desipramine and norzimelidine.
This fact is in accordance with the reported blockage of these compounds of the 5-HT uptake. Furthermore, similar Bmax values were obtained for both radioligands in the brain regions under
study, indicating their binding to the same presynaptic membrane protein. These findings give evidence of the suitability of both [3H]paroxetine and [3H]citalopram as markers of the 5-HT
transporter. However, the higher affinity of [3H] paroxetine (10 to 30-fold with respect to [3H]citalopram) confirms that the radiolabelled form of this compound is the best tool for the
study of the 5-HT uptake site available today. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Geriatric Medicine, Linköping, Sweden Belén Arranz & Jan Marcusson
* Department of Clinical Chemistry (Hormone Unit), Hospital Princeps d'Espanya, Barcelona, Spain Belén Arranz Authors * Belén Arranz View author publications You can also search for
this author inPubMed Google Scholar * Jan Marcusson View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT
THIS ARTICLE CITE THIS ARTICLE Arranz, B., Marcusson, J. [3H]Paroxetine and [3H]Citalopram as Markers of the Human Brain 5-HT Uptake Site. _Neuropsychopharmacol_ 11, 265 (1994).
https://doi.org/10.1038/sj.npp.1380134 Download citation * Published: 25 July 2003 * Issue Date: 01 December 1994 * DOI: https://doi.org/10.1038/sj.npp.1380134 SHARE THIS ARTICLE Anyone you
share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the
Springer Nature SharedIt content-sharing initiative