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ABSTRACT MICE inoculated with an Ehrlich Lettré ascites tumour have a life-span of 2–3 weeks. In the course of ionic balance studies on such mice we noticed that these animals, after being

given lithium, tended to retain more than normal controls. Daily lithium injections (1 ml. of 150 m.equiv./l. lithium chloride subcutaneously) were started on either the fifth or tenth day

after inoculation, and were continued for a further four days. Food and water were given _ad libitum_. On the fifth day the mice were lightly etherized, samples of the ascitic fluid were

with-drawn and blood was obtained by cardiac puncture. Plasma, red blood cells, ascites supernatant fluid and tumour cells were analysed for sodium, potassium and lithium using a Beckman

flame spectrophotometer. All mice were examined for the presence of macroscopic secondary deposits. Access through your institution Buy or subscribe This is a preview of subscription

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PLASMA FOR SURVIVAL PREDICTION IN HEMATOLOGICAL MALIGNANCY CASES Article Open access 02 October 2020 THE MULTIPLE ROLES OF LDH IN CANCER Article 07 October 2022 CHANGES IN RDW ACCORDING TO

PROGNOSTIC PREDICTORS IN NEWLY DIAGNOSED MULTIPLE MYELOMA Article Open access 03 February 2024 REFERENCES * Maizels, M., and Remington, Mary, and Truscoe, R., _J. Physiol._, 140, 48 (1958).

Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Departments of Pharmacology and Physiology, University of Melbourne, SHIRLEY E. SIMON, E. M.

TRAUTNER & D. A. COATS Authors * SHIRLEY E. SIMON View author publications You can also search for this author inPubMed Google Scholar * E. M. TRAUTNER View author publications You can

also search for this author inPubMed Google Scholar * D. A. COATS View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE SIMON, S., TRAUTNER, E. & COATS, D. Lithium Retention in Ascites Tumour Mice. _Nature_ 183, 1128–1129 (1959).

https://doi.org/10.1038/1831128a0 Download citation * Issue Date: 18 April 1959 * DOI: https://doi.org/10.1038/1831128a0 SHARE THIS ARTICLE Anyone you share the following link with will be

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