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ABSTRACT In order to identify a commonly deleted region of 13q14 on chromosome 13, we performed fluorescence _in situ_ hybridization (FISH) on 17 patients with myeloid malignancies and 12

patients with lymphoid leukemia/lymphoma who exhibited either deletion or translocation at 13q14. Three cosmid probes (_RB_, D13S319 and D13S25) hybridizing to sequences on 13q14 were used.

Fourteen of the 17 patients with myeloid malignancies (82.4%) exhibited allelic loss at the _RB_, D13S319 and D13S25 locus, whereas only three of the 12 patients with lymphoid malignancies

(25.0%) exhibited loss within these loci. These three patients had chronic lymphocytic leukemia (CLL). Six, two and one of the remaining nine lymphoid leukemia/lymphoma patients had

breakpoints centromeric to the _RB_ gene, telomeric to D13S25 and within the D13S319 locus, respectively. A high frequency of allelic loss was found using these probes in patients with

myeloid malignancies, compared to in patients with leukemia in the lymphoid origin, except CLL patients. These results indicate that loss of the_ RB_ gene itself or a region between _RB_ and

D13S319, which includes commonly deleted loci, may play an important role in myeloid leukemogenesis. Access through your institution Buy or subscribe This is a preview of subscription

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ADULTS Article Open access 16 August 2022 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Cancer Cytogenetics, Research Institute for Radiation Biology and Medicine, Hiroshima

University, Hiroshima, Japan K Tanaka, M Arif, M Eguchi & N Kamada * Department of Pediatrics, Tokyo University, Tokyo, Japan SX Guo & Y Hayashi * Fourth Department of Internal

Medicine, Hiroshima Red Cross and Atomic Bomb Survivors Hospital, Hiroshima, Japan H Asaoku, T Kyo & H Dohy Authors * K Tanaka View author publications You can also search for this

author inPubMed Google Scholar * M Arif View author publications You can also search for this author inPubMed Google Scholar * M Eguchi View author publications You can also search for this

author inPubMed Google Scholar * SX Guo View author publications You can also search for this author inPubMed Google Scholar * Y Hayashi View author publications You can also search for this

author inPubMed Google Scholar * H Asaoku View author publications You can also search for this author inPubMed Google Scholar * T Kyo View author publications You can also search for this

author inPubMed Google Scholar * H Dohy View author publications You can also search for this author inPubMed Google Scholar * N Kamada View author publications You can also search for this

author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Tanaka, K., Arif, M., Eguchi, M. _et al._ Frequent allelic loss of the

_RB_, D13S319 and D13S25 locus in myeloid malignancies with deletion/translocation at 13q14 of chromosome 13, but not in lymphoid malignancies. _Leukemia_ 13, 1367–1373 (1999).

https://doi.org/10.1038/sj.leu.2401482 Download citation * Received: 19 January 1999 * Accepted: 23 April 1999 * Published: 09 September 1999 * Issue Date: 01 September 1999 * DOI:

https://doi.org/10.1038/sj.leu.2401482 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not

currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * RB gene * deletion of chromosome 13 * AML * MDS *

non-Hodgkin’s lymphoma * ATL