Frequent allelic loss of the rb, d13s319 and d13s25 locus in myeloid malignancies with deletion/translocation at 13q14 of chromosome 13, but not in lymphoid malignancies
- Select a language for the TTS:
- UK English Female
- UK English Male
- US English Female
- US English Male
- Australian Female
- Australian Male
- Language selected: (auto detect) - EN
Play all audios:

ABSTRACT In order to identify a commonly deleted region of 13q14 on chromosome 13, we performed fluorescence _in situ_ hybridization (FISH) on 17 patients with myeloid malignancies and 12
patients with lymphoid leukemia/lymphoma who exhibited either deletion or translocation at 13q14. Three cosmid probes (_RB_, D13S319 and D13S25) hybridizing to sequences on 13q14 were used.
Fourteen of the 17 patients with myeloid malignancies (82.4%) exhibited allelic loss at the _RB_, D13S319 and D13S25 locus, whereas only three of the 12 patients with lymphoid malignancies
(25.0%) exhibited loss within these loci. These three patients had chronic lymphocytic leukemia (CLL). Six, two and one of the remaining nine lymphoid leukemia/lymphoma patients had
breakpoints centromeric to the _RB_ gene, telomeric to D13S25 and within the D13S319 locus, respectively. A high frequency of allelic loss was found using these probes in patients with
myeloid malignancies, compared to in patients with leukemia in the lymphoid origin, except CLL patients. These results indicate that loss of the_ RB_ gene itself or a region between _RB_ and
D13S319, which includes commonly deleted loci, may play an important role in myeloid leukemogenesis. Access through your institution Buy or subscribe This is a preview of subscription
content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue
Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL
ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS HMGA2 OVEREXPRESSION WITH SPECIFIC
CHROMOSOMAL ABNORMALITIES PREDOMINATE IN _CALR AND ASXL1_ MUTATED MYELOFIBROSIS Article Open access 23 December 2024 MLPA AND DNA INDEX IMPROVE THE MOLECULAR DIAGNOSIS OF CHILDHOOD B-CELL
ACUTE LYMPHOBLASTIC LEUKEMIA Article Open access 13 July 2020 CHROMOTHRIPSIS IS A FREQUENT EVENT AND UNDERLIES TYPICAL GENETIC CHANGES IN EARLY T-CELL PRECURSOR LYMPHOBLASTIC LEUKEMIA IN
ADULTS Article Open access 16 August 2022 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Cancer Cytogenetics, Research Institute for Radiation Biology and Medicine, Hiroshima
University, Hiroshima, Japan K Tanaka, M Arif, M Eguchi & N Kamada * Department of Pediatrics, Tokyo University, Tokyo, Japan SX Guo & Y Hayashi * Fourth Department of Internal
Medicine, Hiroshima Red Cross and Atomic Bomb Survivors Hospital, Hiroshima, Japan H Asaoku, T Kyo & H Dohy Authors * K Tanaka View author publications You can also search for this
author inPubMed Google Scholar * M Arif View author publications You can also search for this author inPubMed Google Scholar * M Eguchi View author publications You can also search for this
author inPubMed Google Scholar * SX Guo View author publications You can also search for this author inPubMed Google Scholar * Y Hayashi View author publications You can also search for this
author inPubMed Google Scholar * H Asaoku View author publications You can also search for this author inPubMed Google Scholar * T Kyo View author publications You can also search for this
author inPubMed Google Scholar * H Dohy View author publications You can also search for this author inPubMed Google Scholar * N Kamada View author publications You can also search for this
author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Tanaka, K., Arif, M., Eguchi, M. _et al._ Frequent allelic loss of the
_RB_, D13S319 and D13S25 locus in myeloid malignancies with deletion/translocation at 13q14 of chromosome 13, but not in lymphoid malignancies. _Leukemia_ 13, 1367–1373 (1999).
https://doi.org/10.1038/sj.leu.2401482 Download citation * Received: 19 January 1999 * Accepted: 23 April 1999 * Published: 09 September 1999 * Issue Date: 01 September 1999 * DOI:
https://doi.org/10.1038/sj.leu.2401482 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * RB gene * deletion of chromosome 13 * AML * MDS *
non-Hodgkin’s lymphoma * ATL