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ABSTRACT THE genome of influenza virus consists of eight distinct segments of single stranded RNA as determined by electrophoresis in polyacrylamide gels1–3. Each of these segments codes for

one of the eight virus specified polypeptides4–9 and is therefore believed to be a single gene which functions by a monocistronic messenger RNA10. Because different strains of influenza may

vary in base sequence homology9 or in the electrophoretic mobilities of their RNA segments and infected cell polypeptides11,12, it is often possible to determine the parental origin of

every gene in an interstrain recombinant. Such procedures have been used to investigate the physiological properties associated with some of the influenza virus specified proteins9,13,14. I

describe here the application of this approach to an investigation into the genetic control of host range. The results show that the difference in host range between two avian influenza

viruses depends solely on the properties of one of the internal viral proteins associated with RNA polymerase activity. Access through your institution Buy or subscribe This is a preview of

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EFFECTS ON INFLUENZA PB1 SEGMENT EXTENDS REPLICATION REQUIREMENTS BEYOND THE CANONICAL PROMOTER Article Open access 22 February 2025 COLLECTIVE INTERACTIONS AUGMENT INFLUENZA A VIRUS

REPLICATION IN A HOST-DEPENDENT MANNER Article 06 July 2020 PRECISE PROGRAMMING OF MULTIGENE EXPRESSION STOICHIOMETRY IN MAMMALIAN CELLS BY A MODULAR AND PROGRAMMABLE TRANSCRIPTIONAL SYSTEM

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A1235, Vienna, Austria AUTHORS AND AFFILIATIONS * Division of Virology, Department of Pathology, University of Cambridge, Laboratories Block, Addenbrooke's Hospital, Hills Road,

Cambridge, UK J. W. ALMOND Authors * J. W. ALMOND View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT

THIS ARTICLE CITE THIS ARTICLE ALMOND, J. A single gene determines the host range of influenza virus. _Nature_ 270, 617–618 (1977). https://doi.org/10.1038/270617a0 Download citation *

Received: 07 July 1977 * Accepted: 30 September 1977 * Issue Date: 15 December 1977 * DOI: https://doi.org/10.1038/270617a0 SHARE THIS ARTICLE Anyone you share the following link with will

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