Reader TTS

ABSTRACT A STRIKING structural feature of several cell surface molecules in warm-blooded vertebrates is the non-covalent association of polypeptide chains (molecular weight (MW) 40–45,000)

bearing alloantigenic determinants, with another molecule, _β_2-microglobulin (_β_2m) (MW 11–12,000)1–4. A role for _β_2m has not been established, but a whole family of cell surface

proteins with overall structural similarity to major transplantation antigens have _β_2m as a common invariant subunit. The identification of _β_2m in these proteins has relied mainly on its

characteristically low MW and on the use of heterologous antisera. Human thymus antigen (HTA 1) is a surface antigen found on human thymocytes and certain thymomas like MOLT-4. It has been

identified by the monoclonal antibody from hybrid myeloma NA1/34 and has been suggested to represent the human homologue of the murine TL antigen5. We describe here experiments showing that

the heavy chain of HTA1 is associated with a ‘_β_2m-like’ subunit which is different from _β_2m both in its mobility in SDS polyacrylamide gel electrophoresis (PAGE) and in its immunological

properties. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe

to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF

Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact

customer support SIMILAR CONTENT BEING VIEWED BY OTHERS A GUIDE TO THYMIC SELECTION OF T CELLS Article 18 July 2023 FUNCTIONAL ANTIBODIES EXHIBIT LIGHT CHAIN COHERENCE Article Open access 26

October 2022 THE STRUCTURE OF THE TELEOST IMMUNOGLOBULIN M CORE PROVIDES INSIGHTS ON POLYMERIC ANTIBODY EVOLUTION, ASSEMBLY, AND FUNCTION Article Open access 21 November 2023 REFERENCES *

Nakamuro, K., Tanigaki, N. & Pressman, D. _Proc. natn. Acad. Sci. U.S.A._ 70, 2863–2865 (1973). Article  ADS  CAS  Google Scholar  * Vitetta, E. S. & Capra, J. D. _Adv. Immun._ 26,

147–193 (1978). Article  CAS  Google Scholar  * Finkelman, F. D., Shevach, E. M., Vitetta, E. S., Green, I. & Paul, W. E. _J. exp. Med._ 141, 27–41 (1975). Article  Google Scholar  *

Ziegler, A. & Pink, J. R. L. _Transplantation_ 20, 523–527 (1975). Article  CAS  Google Scholar  * McMichael, A. J. _et al._ _Eur. J. Immun._ (in the press). * Minowada, J., Ohnuma, T.

& Moore, G. E. _J. natn. Cancer Inst._ 49, 891–895 (1972). CAS  Google Scholar  * Ziegler, A. & Pink, J. R. L. _J. biol. Chem._ 251, 5391–5396 (1976). CAS  PubMed  Google Scholar  *

Milstein, C., Galfre, G., Secher, D. S. & Springer, T. _Ciba Fdn Symp._ 66, (in the press). * Snary, D., Goodfellow, P., Hayman, M. J., Bodmer, W. F. & Crumpton, M. J. _Nature_ 247,

457–461 (1974). Article  ADS  CAS  Google Scholar  * Peterson, P. A., Cunningham, B. A., Berggård, I. & Edelman, G. M. _Proc. natn. Acad. Sci. U.S.A._ 69, 1697–1701 (1972). Article  ADS

  CAS  Google Scholar  * Milstein, C. & Svasti, J. in _Progress in Immunology_ (ed. Amos, B.) 33–45 (Academic, New York, 1971). Book  Google Scholar  * Vitetta, E. S., Uhr, J. W. &

Boyse, E. A. _J. Immun._ 114, 252–254 (1975). CAS  PubMed  Google Scholar  * Östberg, L., Rask, L., Wigzell, H. & Peterson, P. A. _Nature_ 253, 735–737 (1975). Article  ADS  Google

Scholar  * Vitetta, E. S., Poulik, M. D., Klein, J. & Uhr, J. W. _J. exp. Med._ 144, 179–192 (1976). Article  CAS  Google Scholar  * Hyman, R. & Trowbridge, I. _Cold Spring Harb.

Symp. quant. Biol._ 41, 407–415 (1977). Article  Google Scholar  * Klein, J., Flaherty, L., Van de Berg, J. L. & Shreffler, D. C. _Immunogenetics_ 6, 489–512 (1978). Article  Google

Scholar  * Michaelson, J., Flaherty, L., Vitetta, E. S. & Poulik, M. D. _J. exp. Med._ 145, 1066–1070 (1977). Article  CAS  Google Scholar  * Tada, N., Tanigaki, N. & Pressman, D.

_J. Immun._ 120, 513–519 (1978). CAS  PubMed  Google Scholar  * Ziegler, A., Harrison, S. C. & Leberman, R. _Virology_ 59, 509–515 (1974). Article  CAS  Google Scholar  * Barnstable, C.

J. _et al._ _Cell_ 14, 9–20 (1978). Article  CAS  Google Scholar  * Laskey, R. A. & Mills, A. D. _FEBS Lett._ 82, 314–316 (1977). Article  CAS  Google Scholar  Download references AUTHOR

INFORMATION Author notes * ANDREAS ZIEGLER Present address: Medizinische Klinik, Abteilung Innere Medizin II, Otfried-Müller-Strasse, D-7400, Tübingen, 1, FRG AUTHORS AND AFFILIATIONS * MRC

Laboratory of Molecular Biology, Hills Road, Cambridge, UK ANDREAS ZIEGLER & CESAR MILSTEIN Authors * ANDREAS ZIEGLER View author publications You can also search for this author

inPubMed Google Scholar * CESAR MILSTEIN View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE ZIEGLER, A., MILSTEIN, C. A small polypeptide different from _β_2-microglobin associated with a human cell surface antigen. _Nature_ 279, 243–244 (1979).

https://doi.org/10.1038/279243a0 Download citation * Received: 30 January 1979 * Accepted: 04 April 1979 * Issue Date: 17 May 1979 * DOI: https://doi.org/10.1038/279243a0 SHARE THIS ARTICLE

Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided

by the Springer Nature SharedIt content-sharing initiative