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AAA+ proteases are quality control machineries consisting of substrate-binding ATPase modules for protein unfolding and a proteolytic chamber. New research now shows a redox switch in the

_Escherichia coli_ Lon protease that controls this process, widening the exit pore and activating proteolysis during transition from anaerobic to aerobic environments. Access through your

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R.T. & Baker, T.A. _Annu. Rev. Biochem._ 80, 587–612 (2011). Article  CAS  Google Scholar  * Neuwald, A.F., Aravind, L., Spouge, J.L. & Koonin, E.V. _Genome Res._ 9, 27–43 (1999).

CAS  PubMed  Google Scholar  * Van Melderen, L. & Aertsen, A. _Res. Microbiol._ 160, 645–651 (2009). Article  CAS  Google Scholar  * Nishii, W. et al. _Nat. Chem. Biol._

10.1038/nchembio.1688 (10 November 2014). * Antelmann, H. & Helmann, J.D. _Antioxid. Redox Signal._ 14, 1049–1063 (2011). Article  CAS  Google Scholar  * Newberry, K.J., Fuangthong, M.,

Panmanee, W., Mongkolsuk, S. & Brennan, R.G. _Mol. Cell_ 28, 652–664 (2007). Article  CAS  Google Scholar  * Choi, H. et al. _Cell_ 105, 103–113 (2001). Article  CAS  Google Scholar  *

Jakob, U., Muse, W., Eser, M. & Bardwell, J.C. _Cell_ 96, 341–352 (1999). Article  CAS  Google Scholar  * Voth, W. et al. _Mol. Cell_ 56, 116–127 (2014). Article  CAS  Google Scholar  *

Zhang, Y. & Zuber, P. _J. Bacteriol._ 186, 7669–7680 (2007). Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Haike Antelmann is at the

Institute for Microbiology, Ernst-Moritz-Arndt-University of Greifswald, Greifswald, Germany., Haike Antelmann Authors * Haike Antelmann View author publications You can also search for this

author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Haike Antelmann. ETHICS DECLARATIONS COMPETING INTERESTS The author declares no competing financial interests. RIGHTS

AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Antelmann, H. A thiol switch opens the gate. _Nat Chem Biol_ 11, 4–5 (2015).

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