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Access through your institution Buy or subscribe Mille _et al_. have shown that the sonic hedgehog (SHH) receptor BOC, which is required to form a functional complex with Patched (PTCH1),

mediates medulloblastoma progression. The authors found that BOC is upregulated in medulloblastomas with activated SHH signalling. Inactivation of _Boc_ in medulloblastoma mouse models

reduced tumour size and progression. BOC increases cell proliferation by regulating levels of cyclin D1. BOC also promotes DNA damage, increasing the incidence of _Ptch1_ loss of

heterozygosity, which drives tumour progression. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this

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support REFERENCES * Mille, F. et al. The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors. _Dev. Cell_ http://dx.doi.org/10.1016/j.devcel.2014.08.010 (2014)

Download references Authors * M. Teresa Villanueva View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT

THIS ARTICLE CITE THIS ARTICLE Villanueva, M. BOC's plot thickens. _Nat Rev Cancer_ 14, 706 (2014). https://doi.org/10.1038/nrc3850 Download citation * Published: 24 October 2014 *

Issue Date: November 2014 * DOI: https://doi.org/10.1038/nrc3850 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

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