Reader TTS

ABSTRACT Indomethacin (I) was studied in the isolated, perfused immature (27 days' gestation) fetal rabbit lung. Lungs contained normal volume of fetal pulmonary fluid (FPF) during

pulmonary vascular perfusion with either balanced, buffered electrolyte solution (BES), 3% 02 (C, control, n=5) or BES, 3% 02, plus .50 μg/ml I (n=5). Within 5 min of start of perfusion, the

ductus was ligated and after 1.5-2 h, the lungs were inflated to maximal volume, then deflated to atmospheric pressure, the first air volume-pressure (VP) diagram. PVR was the same in both

groups at the start and immediately after ductal ligation when PVR increased. However, after 1.5-2 h C PVR had returned to pre-ligation level, whereas I PVR remained elevated. When the lungs

were inflated, PVR decreased in C, but increased in I. With deflation C PVR did not change and I PVR decreased to pre-inflation level. Comparison of VP diagrams with age-matched, but

unperfused fetal lungs showed larger volumes and greater air retention in C, but no difference from I. These studies indicate that (1) “resting” prostaglandin (PG) activity is minimal in the

isolated, perfused immature fetal lung; (2) normal accommodation to volume load produced by ductal closure may be mediated by PG and is blocked by I; (3) pulmonary vascular perfusion itself

may induce surfactant release (which is blocked indirectly by I) into FPF; and (4) PVR decrease during inflation is related, in part, to PG activity and/or surfactant release. (Supported by

NIH HL 07060). ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Pediatric Pulmonary Division, Albert Einstein College of Medicine, Bronx, N.Y. Cathy A Hemmerman & Emile M

Scarpelli Authors * Cathy A Hemmerman View author publications You can also search for this author inPubMed Google Scholar * Emile M Scarpelli View author publications You can also search

for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hemmerman, C., Scarpelli, E. 1662 INDOMETHACIN, IMMATURE FETAL

PULMONARY VASCULAR RESISTANCE (PVR), AND LUNG INFLATION. _Pediatr Res_ 15 (Suppl 4), 720 (1981). https://doi.org/10.1203/00006450-198104001-01680 Download citation * Issue Date: 01 April

1981 * DOI: https://doi.org/10.1203/00006450-198104001-01680 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative