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ABSTRACT Summary: We compared the absorption of carbohydrate from solutions of glucose oligomers and glucose in jejunal Thiry-Vella fistulae, a preparation deprived of pancreatic secretions.

The studies were performed with two concentrations (90 and 360 mg/dl) of both glucose and the glucose oligomers. Carbohydrate absorption from glucose solutions (33.1 × 2.8, 115.9 × 8.9

μg/cm/min) was significantly greater (_P_ < 0.025; _P_ < 0.005) than that from oligomer solutions (26.6 × 2.1 and 92.4 × 9.0 μg/cm/min). Thin-layer analyses of the perfusates

demonstrate digestion of oligomers with a chain length up to eleven and suggest digestion of oligomers of even greater chain length. Atrophy of the jejunal mucosa occurred over the course of

the study as evidenced by a decrease in the ratio of villous height to crypt depth from 3.8 to 0.3, and by a 80% decrease in the activity of maltase, sucrase, and lactase. Atrophy was

accompanied by a significant decline in the absorption of both glucose oligomers (_P_ < 0.005) and glucose (_P_ < 0.01) from the more concentrated solutions but the decrement in

absorption of both carbohydrates was similar, glucose oligomers, 79.3 × 19.4 μg/cm/min; and glucose, 69.8 × 14 μg/cm/min (_P_ > 0.20). Water absorption was enhanced by both carbohydrates,

but there was no demonstrable difference between solutions of glucose and glucose oligomers. The osmolality of the solutions clearly influenced water absorption (_P_ < 0.025) but failed

to effect the absorption of carbohydrates. Speculation: In patients with pancreatic insufficiency, solutions of glucose oligomers with low osmolality may provide an adequate source of

calories. Although glucose is better absorbed than glucose oligomers from a short segment of jejunum, the length of the small intestine should be adequate to compensate for this

difference.~h~ absorption of the glucose oligomers may be a function of polymer length and therefore studies with subfractions separated according to chain length will demonstrate which

oligomers are most efficiently absorbed. such information may provide the theoretical hasis for the construction of an ideal carbohydrate supplement for patients with pancreatic

insufficiency. SIMILAR CONTENT BEING VIEWED BY OTHERS NEOKESTOSE SUPPRESSES THE INCREASE IN PLASMA GLUCOSE CAUSED BY ORAL ADMINISTRATION OF SUCROSE IN A STREPTOZOTOCIN‑INDUCED DIABETIC RAT

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INTRAGASTRIC ADMINISTRATION OF L-TRYPTOPHAN ON THE GLYCAEMIC RESPONSE TO A NUTRIENT DRINK IN MEN WITH TYPE 2 DIABETES — IMPACTS ON GASTRIC EMPTYING, GLUCOREGULATORY HORMONES AND GLUCOSE

ABSORPTION Article Open access 05 January 2021 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, Ohio State University, Children's Hospital, 700

Children's Drive, Columbus, Ohio, USA Benny Kerzner, Howard R Sloan, Gerald Haase, H Juhling Mcclung & Anton H Ailabouni Authors * Benny Kerzner View author publications You can

also search for this author inPubMed Google Scholar * Howard R Sloan View author publications You can also search for this author inPubMed Google Scholar * Gerald Haase View author

publications You can also search for this author inPubMed Google Scholar * H Juhling Mcclung View author publications You can also search for this author inPubMed Google Scholar * Anton H

Ailabouni View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kerzner,

B., Sloan, H., Haase, G. _et al._ The Jejunal Absorption of Glucose Oligomers in the Absence of Pancreatic Enzymes. _Pediatr Res_ 15, 250–253 (1981).

https://doi.org/10.1203/00006450-198103000-00010 Download citation * Issue Date: 01 March 1981 * DOI: https://doi.org/10.1203/00006450-198103000-00010 SHARE THIS ARTICLE Anyone you share the

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Nature SharedIt content-sharing initiative KEYWORDS * glucose * glucose oligomers * intestine * pancreatic enzymes