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ABSTRACT Stunted growth after irradiation of the head only of the neonatal rat is unexplained. Prior studies show no relationship to food intake and no response to growth hormone and/or

thyroxine. Male and female rats were X-irradiated with 600 rads limited to the head at 2 days of age. Controls were non-irradiated littermates. Irradiation resulted in retarded growth of

body weight and tail length beginning prior to weaning; catch-up growth did not occur. Costal cartilage at ages 21 days (d), 40 d and 70 d was incubated 20 h at 37C in serum-free medium (M)

consisting of phosphosaline buffer, pH 7.4, amino acids, glucose and antibiotics or in medium with 10 percent pooled normal rat serum (MS). 35S-sulfate (S), 3H-thymidine (T), 14C-leucine (L)

or 3H-proline (P) were added to media. In M irradiated rats had significantly increased incorporation of P at 21 d and 40 d and L at 40 d; there was no change in S. In MS irradiated rats

had significantly increased incorporation of S and L at 21 d and 40 d. T incorporation was not increased over controls at any age in M or MS. We conclude that in stunted head-irradiated rats

synthesis in cartilage of sulfated proteoglycans and collagen is increased and/or hyperresponsive to normal serum. That T incorporation is not increased is compatible with the possibility

that failure in catch-up growth of bones after head irradiation results from inhibition of mitosis of chondrocytes. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of

Pediatrics, University of California, Irvine, California H David Mosier Jr., Charles A Sondhaus, Oscar F Zuniga, Regina A Jansons, Cynthia S Biggs & Rosalinda C Roberts Authors * H David

Mosier Jr. View author publications You can also search for this author inPubMed Google Scholar * Charles A Sondhaus View author publications You can also search for this author inPubMed 

Google Scholar * Oscar F Zuniga View author publications You can also search for this author inPubMed Google Scholar * Regina A Jansons View author publications You can also search for this

author inPubMed Google Scholar * Cynthia S Biggs View author publications You can also search for this author inPubMed Google Scholar * Rosalinda C Roberts View author publications You can

also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Mosier, H., Sondhaus, C., Zuniga, O. _et al._ 432

CHONDROCYTE FUNCTION IS DISTURBED IN RATS WITH STUNTED GROWTH FOLLOWING NEONATAL X-IRRADIATION LIMITED TO THE HEAD. _Pediatr Res_ 15 (Suppl 4), 512 (1981).

https://doi.org/10.1203/00006450-198104001-00443 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00443 SHARE THIS ARTICLE Anyone you share the

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