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ABSTRACT We have compared 1.5 gm meat protein/kg ideal body weight (IBW)/d and either 1 gm glucose/kg IBW/d (P+G) or an isocaloric quantity of fat (P+F) in a crossover study of 8 obese

adolescents. IBW was determined by measuring total body water with H2O18. Each diet period lasted 21 days, separated by one month of weight maintenance. Before and after each dietary period,

rates of hepatic glucose production (Ra) were measured using a primed constant infusion of U−13C-glucose. Nitrogen balance (N-bal) was determined weekly. All subjects had a coefficient of

variation of daily urinary creatinine excretion < 13%. Three week cumulative N-bal was significantly better (p< .02) on P+G. Ra was significantly lower than baseline on both diets but

Ra on P+G was similar to P+F. Free fatty acid and insulin levels measured during the infusion did not differ on the two diets. Ketone bodies were significantly lower, and plasma glucose

significantly higher on P+G. Ra correlated with N-bal on P+F (r = 0.87, p < .01) but not on P+G, even when 24h Ra was calculated and adjusted for glucose (G) intake. Dietary carbohydrate

does not appear to influence N-bal by reducing the hepatic demand for gluconeogenic substrate. Since % of CO2 from glucose was decreased on P+F, decreased utilization of G may partially

account for these differences. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of GI-Nutrition, Children's Hospital Medical Center, Boston William H Dietz, Robert R

Wolfe & R J Grand * Department of Surgery, Massachusetts General Hospital, Boston William H Dietz, Robert R Wolfe & R J Grand Authors * William H Dietz View author publications You

can also search for this author inPubMed Google Scholar * Robert R Wolfe View author publications You can also search for this author inPubMed Google Scholar * R J Grand View author

publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Dietz, W., Wolfe, R. &

Grand, R. 540 OPTIMAL DIETARY THERAPY FOR OBESE ADOLESCENTS: EFPECTS OF DIETARY GLUCOSE OR FAT ON THE INTERRELATIONSHIPS OF PROTEIN AND GLUCOSE METABOLISM. _Pediatr Res_ 15 (Suppl 4), 530

(1981). https://doi.org/10.1203/00006450-198104001-00554 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00554 SHARE THIS ARTICLE Anyone you

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