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ABSTRACT We reported higher plasma ANP-levels in newborns than in older children. It was speculated that elevated ANP-levels may result in a down-regulation of ANP-binding sites. To prove

this hypothesis we measured ANP together with the second messenger cGMP and ANP-binding sites on platelets in the perinatal period. Plasma ANP- and cGMP-levels were determined in mothers

after vaginal delivery (n=21) and after sectio (n=7) and in umbilical venous (n=27) and arterial (n=15) cord blood of term newborns. ANP-binding sites on platelets were determined in cord

blood. ANP- and cGMP-levels were significantly higher in mothers and in cord blood than in non-pregnant women (n=11) and in control infants beyond the neonatal period, resp. (n=18,

p<0,01). There was a linear correlation between ANP- and cGMP-levels (r=0,7). There were no significant differences in ANP-binding sites/platelet and Kd between newborns and healthy

adults (n=19). Our results do not support the hypothesis of a down-regulation of “ANP-receptors” in the perinatal period. The elevated cGMP levels in patients with high ANP-levels agree with

the concept that cGMP is a Marker for the cellular effects of ANP. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Depart, of Pediatrics, University of Munich, FRG J Well, T Strom

 & A Timnik * Depart, of Medicine, University of Munich, FRG R Gerzer Authors * J Well View author publications You can also search for this author inPubMed Google Scholar * T Strom View

author publications You can also search for this author inPubMed Google Scholar * A Timnik View author publications You can also search for this author inPubMed Google Scholar * R Gerzer

View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Well, J., Strom, T.,

Timnik, A. _et al._ PLASMA ATRIAL NATRIURETIC PEPTIDE (ANP) AND CYCLIC GUANOSINE MONOPHOSPHATE (cGMP) LEVELS AND ANP-BINDING SITES ON PLATELETS IN THE PERINATAL PERIOD. _Pediatr Res_ 26,

509 (1989). https://doi.org/10.1203/00006450-198911000-00058 Download citation * Issue Date: 01 November 1989 * DOI: https://doi.org/10.1203/00006450-198911000-00058 SHARE THIS ARTICLE

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